| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4323785 | F | Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 2. | ALA4323786 | A | Agonist activity at human luteinizing hormone receptor incubated for 60 mins by cell based TR-FRET assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4323787 | F | Downregulation of human luteinizing hormone-induced COX-2 mRNA expression in cetrorelix-treated iv dosed female rat after 2 hrs by Taqman probe based RT-PCR analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA4323788 | F | Reversal of human luteinizing hormone-induced suppression of aromatase mRNA expression in cetrorelix-treated iv dosed female rat after 2 hrs by Taqman probe based RT-PCR analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4323789 | F | Downregulation of human luteinizing hormone-induced RUNX1 mRNA expression in cetrorelix-treated iv dosed female rat after 2 hrs by Taqman probe based RT-PCR analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA4323790 | F | Downregulation of human luteinizing hormone-induced Egr-1 mRNA expression in cetrorelix-treated iv dosed female rat after 2 hrs by Taqman probe based RT-PCR analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4323791 | B | Negative allosteric modulation of human luteinizing hormone receptor assessed as Emax for glycoprotein human luteinizing hormone-induced agonist activity at 0.84 nM to 17 uM preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4323792 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 2 uM after 2 hrs by LC-MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4323793 | B | Agonist activity at human A2B receptor expressed in HEK293 cells at 10 uM after 10 mins by HTRF assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4323794 | F | Antagonist activity at human follicle stimulating hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition and measured after 120 mins by cell based TR-FRET assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA4323796 | F | Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA4323797 | F | Antagonist activity at human thyroid stimulating hormone receptor expressed in rat HTC133 cells assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition and measured after 60 mins by cell based TR-FRET assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA4323799 | P | Lipophilicity, logD of the compound at pH 7.5 by reversed-phase HPLC | 32 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA4323800 | A | Clearance in human liver microsomes at 1 uM measured after 2 to 60 mins in presence of glucose-6-phosphate by LC-MS/MS analysis | Homo sapiens | 30 | microsome format | Scientific Literature | ||
| 15. | ALA4323801 | A | Maximum oral bioavailability in human liver microsomes based well stirred liver model at 1 uM measured after 2 to 60 mins in presence of glucose-6-phosphate by LC-MS/MS analysis | Homo sapiens | 30 | organism-based format | Scientific Literature | ||
| 16. | ALA4323802 | B | Antagonist activity at cynomolgus monkey luteinizing hormone receptor expressed in HEK293 cells assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition and measured after 30 mins by cell based TR-FRET assay | Macaca fascicularis | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4323803 | A | Protein binding in human plasma assessed as unbound fraction | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
| 18. | ALA4323804 | B | Inhibition of human ERG expressed in HEK293 cells at holding potential -80 mV by whole-cell voltage-clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4323805 | P | Aqueous solubility of the compound at pH 6.5 incubated for 24 hrs under shaking condition by HPLC-MS/MS analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 20. | ALA4323806 | P | Chemical stability of the compound at pH 1 to 10 measured after 1 to 24 hrs by HPLC-UV method | 2 | small-molecule physicochemical format | Scientific Literature |
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