| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4415059 | Functional | Resistance index, ratio of EC50 for antiviral activity against NS3 T606A mutant containing Dengue virus 2 isolate P12-II infected in human HuH7 cells using viral isolates selected by serial passaging in presence of DMSO incubated for 3 days by viral reduction assay to EC50 for antiviral activity against Dengue virus 2 isolate P0 infected in human HuH7 cells incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 2. | ALA4415060 | Functional | Resistance index, ratio of EC50 for antiviral activity against NS3 T606A mutant containing Dengue virus 2 isolate P12-I infected in human HuH7 cells using viral isolates selected by serial passaging in presence of DMSO incubated for 3 days by viral reduction assay to EC50 for antiviral activity against Dengue virus 2 isolate P0 infected in human HuH7 cells incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 3. | ALA4415061 | Functional | Antiviral activity against Dengue virus 2 isolate P0 infected in human HuH7 cells incubated for 3 days by viral reduction assay | dengue virus type 2 | 2 | ALA4414551 | organism-based format | Scientific Literature | |
| 4. | ALA4415062 | Functional | Antiviral activity against NS3 T606A mutant and NS4B V63L mutant containing Dengue virus 2 isolate P12-VI infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 5. | ALA4415063 | Functional | Antiviral activity against NS4B V63M and P104S mutant containing Dengue virus 2 isolate P12-V infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 6. | ALA4415064 | Functional | Antiviral activity against NS4B V63M mutant containing Dengue virus 2 isolate P12-IV infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 7. | ALA4415065 | Functional | Antiviral activity against NS3 T606A mutant and NS4B V63M mutant containing Dengue virus 2 isolate P12-III infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 8. | ALA4415066 | Functional | Antiviral activity against NS3 T606A mutant containing Dengue virus 2 isolate P12-II infected in human HuH7 cells using viral isolates selected by serial passaging in presence of DMSO incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 9. | ALA4415067 | Functional | Antiviral activity against NS3 T606A mutant containing Dengue virus 2 isolate P12-I infected in human HuH7 cells using viral isolates selected by serial passaging in presence of DMSO incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 10. | ALA4415071 | ADME | Cytotoxicity in human HuH7 replicon cells infected with Dengue virus 2 NGC assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-Glo reagent based assay | Homo sapiens | 63 | ALA4414551 | cell-based format | Scientific Literature | |
| 11. | ALA4415072 | Functional | Antiviral activity against Dengue virus 4 D4MY01-22713 infected in human HuH7 replicon cells expressing Renilla luciferase and neomycin-resistance genes assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter replicon-based assay | dengue virus type 4 | 58 | ALA4414551 | organism-based format | Scientific Literature | |
| 12. | ALA4415073 | Functional | Antiviral activity against Dengue virus 3 D3MY05-34640 infected in human HuH7 replicon cells expressing Renilla luciferase and neomycin-resistance genes assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter replicon-based assay | dengue virus type 3 | 60 | ALA4414551 | organism-based format | Scientific Literature | |
| 13. | ALA4415074 | Functional | Antiviral activity against Dengue virus 2 NGC infected in human HuH7 replicon cells expressing Renilla luciferase and neomycin-resistance genes assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter replicon-based assay | dengue virus type 2 | 63 | ALA4414551 | organism-based format | Scientific Literature | |
| 14. | ALA4415075 | Functional | Antiviral activity against Dengue virus 1 WestPac infected in human HuH7 replicon cells expressing Renilla luciferase and neomycin-resistance genes assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter replicon-based assay | dengue virus type 1 | 58 | ALA4414551 | organism-based format | Scientific Literature | |
| 15. | ALA4415076 | Functional | Resistance index, ratio of EC50 for antiviral activity against NS3 T606A mutant and NS4B V63M mutant containing Dengue virus 2 isolate P12-III infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay to EC50 for antiviral activity against Dengue virus 2 isolate P0 infected in human HuH7 cells incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 16. | ALA4415077 | Functional | Resistance index, ratio of EC50 for antiviral activity against NS4B V63M mutant containing Dengue virus 2 isolate P12-IV infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay to EC50 for antiviral activity against Dengue virus 2 isolate P0 infected in human HuH7 cells incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 17. | ALA4415078 | Functional | Resistance index, ratio of EC50 for antiviral activity against NS4B V63M and P104S mutant containing Dengue virus 2 isolate P12-V infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay to EC50 for antiviral activity against Dengue virus 2 isolate P0 infected in human HuH7 cells incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature | |
| 18. | ALA4415079 | Functional | Resistance index, ratio of EC50 for antiviral activity against NS3 T606A mutant and NS4B V63L mutant containing Dengue virus 2 isolate P12-VI infected in human HuH7 cells using viral isolates selected by serial passaging in presence of test compound incubated for 3 days by viral reduction assay to EC50 for antiviral activity against Dengue virus 2 isolate P0 infected in human HuH7 cells incubated for 3 days by viral reduction assay | dengue virus type 2 | 1 | ALA4414551 | organism-based format | Scientific Literature |
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