# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4425654 | F | Antitumor activity against mouse C26 cells allografted in mouse assessed as tumor growth inhibition at 5 mg/kg, iv qd administered every 2 days measured during compound dosing | Mus musculus | 7 | ALA4425100 | organism-based format | Scientific Literature | |
2. | ALA4425655 | F | Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay | Homo sapiens | 60 | ALA4425100 | cell-based format | Scientific Literature | |
3. | ALA4425656 | F | Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay | Homo sapiens | 60 | ALA4425100 | cell-based format | Scientific Literature | |
4. | ALA4425657 | F | Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay | Homo sapiens | 60 | ALA4425100 | cell-based format | Scientific Literature | |
5. | ALA4425658 | P | Solubility of the compound in 2.5% ethanol/2.5% Tween-80 at 1 mg | 35 | ALA4425100 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4425659 | F | Antiproliferative activity against mouse C26 cells after 24 hrs by MTT assay | Mus musculus | 7 | ALA4425100 | cell-based format | Scientific Literature | |
7. | ALA4425660 | F | Antiproliferative activity against human HCT8 cells after 24 hrs by MTT assay | Homo sapiens | 11 | ALA4425100 | cell-based format | Scientific Literature | |
8. | ALA4425661 | F | Antiproliferative activity against human NCI-H358 cells after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4425100 | cell-based format | Scientific Literature | |
9. | ALA4425662 | F | Antiproliferative activity against human H460 cells after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4425100 | cell-based format | Scientific Literature | |
10. | ALA4425663 | F | Antiproliferative activity against human SKHEP1 cells after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4425100 | cell-based format | Scientific Literature | |
11. | ALA4425664 | F | Antiproliferative activity against human Bel7402 cells after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4425100 | cell-based format | Scientific Literature | |
12. | ALA4425665 | F | Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay | Homo sapiens | 11 | ALA4425100 | cell-based format | Scientific Literature | |
13. | ALA4425666 | F | Antiproliferative activity against human ZR-75-1 cells after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4425100 | cell-based format | Scientific Literature | |
14. | ALA4425667 | F | Antiproliferative activity against human ES2 cells after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4425100 | cell-based format | Scientific Literature | |
15. | ALA4425668 | F | Antiproliferative activity against human A2780S cells after 24 hrs by MTT assay | Homo sapiens | 11 | ALA4425100 | cell-based format | Scientific Literature | |
16. | ALA4425669 | F | Antiproliferative activity against human DU145 cells after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4425100 | cell-based format | Scientific Literature | |
17. | ALA4425670 | B | Binding affinity to tubulin in human HepG2 cells assessed as inhibition of microtubule network formation in cytosol at 100 nM after 16 to 24 hrs by DAPI staining-based immunofluorescence microscopy | Homo sapiens | 8 | ALA4425100 | cell-based format | Scientific Literature | |
18. | ALA4425671 | B | Binding affinity to tubulin in human HepG2 cells assessed as induction of abnormal chromosomal aggregation at 100 nM after 16 to 24 hrs by DAPI staining-based immunofluorescence microscopy | Homo sapiens | 8 | ALA4425100 | cell-based format | Scientific Literature | |
19. | ALA4425672 | F | Antitumor activity against human H460 cells xenografted in mouse assessed as tumor growth inhibition at 10 mg/kg, iv qd administered every 2 days measured during compound dosing | Homo sapiens | 1 | ALA4425100 | organism-based format | Scientific Literature | |
20. | ALA4425673 | T | Toxicity in mouse xenografted with human H460 cells assessed as body weight loss at 10 mg/kg, iv qd administered every 2 days measured daily during compound dosing | Mus musculus | 1 | ALA4425100 | organism-based format | Scientific Literature |