| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4380813 | F | In vivo inhibition of GC formation in in NP-CGG immunized C57BL/6 mouse assessed as impairment in immunoglobulin affinity maturation by measuring decrease in titers of high affinity IgG1 specific for NP5-BSA at 10 mg/kg, iv administered 3 days once for 12 days starting from 2 days after NP-CGG addition by ELISA | Mus musculus | 1 | ALA4376875 | organism-based format | Scientific Literature | |
| 2. | ALA4380816 | B | Inhibition of recombinant human C-terminal GST-tagged BCL6 BTB domain C8Q/C67R/C84N triple mutant expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in SMRT/BTB domain interaction incubated for 1 hr by HTRF assay | Homo sapiens | 32 | ALA4376875 | cell-based format | Scientific Literature | |
| 3. | ALA4380817 | B | Potency index, ratio of IC50 of 3-[5-(5-chloro-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl]propanoic acid to IC50 of compound for inhibition of recombinant human C-terminal GST-tagged BCL6 BTB domain C8Q/C67R/C84N triple mutant expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in SMRT/BTB domain interaction incubated for 1 hr by HTRF assay | Homo sapiens | 2 | ALA4376875 | cell-based format | Scientific Literature | |
| 4. | ALA4380818 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of p53 mRNA expression at 5 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | ALA4376875 | cell-based format | Scientific Literature | |
| 5. | ALA4380819 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of ATR mRNA expression at 5 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 5 | ALA4376875 | cell-based format | Scientific Literature | |
| 6. | ALA4380820 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of CXCR4 mRNA expression at 5 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 5 | ALA4376875 | cell-based format | Scientific Literature | |
| 7. | ALA4380821 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of CD69 mRNA expression at 5 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 5 | ALA4376875 | cell-based format | Scientific Literature | |
| 8. | ALA4380822 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of CDKN1A mRNA expression at 5 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | ALA4376875 | cell-based format | Scientific Literature | |
| 9. | ALA4380828 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of p53 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 10. | ALA4380829 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of ATR mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 11. | ALA4380830 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of CD69 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 12. | ALA4380831 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of CXCR4 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 13. | ALA4380832 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of CDKN1A mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 14. | ALA4380833 | B | Inhibition of BCL6 in human SUDHL4 cells assessed as de-repression of CD80 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 15. | ALA4380834 | B | Inhibition of BCL6 in human FARAGE cells assessed as de-repression of p53 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 16. | ALA4380835 | B | Inhibition of BCL6 in human FARAGE cells assessed as de-repression of ATR mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 17. | ALA4380836 | B | Inhibition of BCL6 in human FARAGE cells assessed as de-repression of CD69 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 18. | ALA4380837 | B | Inhibition of BCL6 in human FARAGE cells assessed as de-repression of CXCR4 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 19. | ALA4380838 | B | Inhibition of BCL6 in human FARAGE cells assessed as de-repression of CDKN1A mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature | |
| 20. | ALA4380839 | B | Inhibition of BCL6 in human FARAGE cells assessed as de-repression of CD80 mRNA expression incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4376875 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!