# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4316027 | B | Activation of recombinant human GABA receptor alpha1beta2gamma2 expressed in CHO cells and measured for 120 secs by FMP dye based FLIPR assay | Homo sapiens | 2 | ALA4312021 | cell-based format | Scientific Literature | |
2. | ALA4316028 | T | Neurotoxicity in ip dosed Kunming mouse assessed as reduction in equilibrium measured after 30 mins by rotarod test | Mus musculus | 5 | ALA4312021 | organism-based format | Scientific Literature | |
3. | ALA4316029 | F | Antiepileptic actvity in C57BL/6 mouse Primary cortical neuron assessed as reduction in 4-AP-induced excitability measured for 8 mins by Fluo-8/AM staining based FLIPR assay | Mus musculus | 15 | ALA4312021 | cell-based format | Scientific Literature | |
4. | ALA4316032 | F | Anticonvulsant activity in Kunming mouse assessed as reduction in MES-induced seizure at 30 to 300 mg/kg, ip measured after 30 mins | Mus musculus | 28 | ALA4312021 | organism-based format | Scientific Literature | |
5. | ALA4316033 | F | Anticonvulsant activity in Kunming mouse assessed as reduction in ScPTZ-induced seizure at 30 mg/kg, ip administered before 30 mins of ScPTZ stimulation | Mus musculus | 28 | ALA4312021 | organism-based format | Scientific Literature | |
6. | ALA4316034 | F | Anticonvulsant activity in Kunming mouse assessed as reduction in ScPTZ-induced seizure at 100 mg/kg, ip administered before 30 mins of ScPTZ stimulation | Mus musculus | 28 | ALA4312021 | organism-based format | Scientific Literature | |
7. | ALA4316035 | F | Anticonvulsant activity in Kunming mouse assessed as reduction in ScPTZ-induced seizure at 300 mg/kg, ip administered before 30 mins of ScPTZ stimulation | Mus musculus | 28 | ALA4312021 | organism-based format | Scientific Literature | |
8. | ALA4316036 | F | Anticonvulsant activity in ip dosed Kunming mouse assessed as reduction in ScPTZ-induced seizure administered before 30 mins of ScPTZ stimulation | Mus musculus | 5 | ALA4312021 | organism-based format | Scientific Literature | |
9. | ALA4316037 | T | Protective index, ratio of TD50 for neurotoxicity in ip dosed Kunming mouse to ED50 for anticonvulsant activity in ip dosed Kunming mouse | Mus musculus | 5 | ALA4312021 | organism-based format | Scientific Literature | |
10. | ALA4316038 | B | Activation of recombinant human GABA receptor alpha1beta2gamma2 expressed in CHO cells in presence of GABA and measured for 120 secs by FMP dye based FLIPR assay | Homo sapiens | 2 | ALA4312021 | cell-based format | Scientific Literature | |
11. | ALA4316039 | B | Positive allosteric modulation of recombinant human GABA receptor alpha1beta2gamma2 expressed in CHO cells at 30 uM in presence of GABA and measured for 120 secs by FMP dye based FLIPR assay (Rvb = 0.25 +/- 0.03 uM) | Homo sapiens | 2 | ALA4312021 | cell-based format | Scientific Literature | |
12. | ALA4316040 | B | Inhibition of sodium channel in C57BL/6 mouse primary cortical neurons at 10 uM by manual patch clamp electrophysiology method | Mus musculus | 2 | ALA4312021 | assay format | Scientific Literature | |
13. | ALA4316041 | B | Inhibition of sodium channel in C57BL/6 mouse Primary cortical neurons at 100 uM by manual patch clamp electrophysiology method | Mus musculus | 2 | ALA4312021 | assay format | Scientific Literature |