# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4426156 | B | Displacement of [3H]-pentazocine from rat brain sigma1 receptor by PDSP assay | Rattus norvegicus | 46 | ALA4425114 | assay format | Scientific Literature | |
2. | ALA4426157 | B | Displacement of [3H]DTG from rat brain sigma2 receptor by PDSP assay | Rattus norvegicus | 46 | ALA4425114 | assay format | Scientific Literature | |
3. | ALA4426158 | B | Displacement of [3H]-pentazocine from rat brain sigma1 receptor at 10 uM by PDSP assay | Rattus norvegicus | 9 | ALA4425114 | assay format | Scientific Literature | |
4. | ALA4426160 | B | Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 mins | Homo sapiens | 6 | ALA4425114 | cell-based format | Scientific Literature | |
5. | ALA4426161 | B | Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells measured after 30 mins | Homo sapiens | 6 | ALA4425114 | cell-based format | Scientific Literature | |
6. | ALA4426162 | B | Displacement of [3H]citalopram from human SERT expressed in HEK293 cells measured after 30 mins | Homo sapiens | 6 | ALA4425114 | cell-based format | Scientific Literature | |
7. | ALA4426163 | B | Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells at 10 uM measured after 30 mins | Homo sapiens | 6 | ALA4425114 | cell-based format | Scientific Literature | |
8. | ALA4426164 | B | Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells at 10 uM measured after 30 mins | Homo sapiens | 6 | ALA4425114 | cell-based format | Scientific Literature | |
9. | ALA4426165 | B | Displacement of [3H]citalopram from human SERT expressed in HEK293 cells at 10 uM measured after 30 mins | Homo sapiens | 6 | ALA4425114 | cell-based format | Scientific Literature | |
10. | ALA4426166 | B | Binding affinity to sigma1 receptor form guinea pig brain membrane in presence of phenytoin by FRET assay | Cavia porcellus | 6 | ALA4425114 | assay format | Scientific Literature | |
11. | ALA4426167 | F | Antinociceptive activity in Kun Ming mouse assessed as reduction in paw licking and flinching time at 80 mg/kg, ip administered 15 mins prior to formalin challenge measured up to 45 mins post formalin dosing relative to vehicle-treated control | Mus musculus | 2 | ALA4425114 | organism-based format | Scientific Literature | |
12. | ALA4426168 | F | Antinociceptive activity in Kun Ming mouse assessed as reduction in paw licking and flinching time at 40 mg/kg, ip administered 15 mins prior to formalin challenge measured after 0 to 10 mins post formalin dosing relative to vehicle-treated control | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature | |
13. | ALA4426169 | F | Antinociceptive activity in Kun Ming mouse assessed as reduction in paw licking and flinching time at 40 mg/kg, ip administered 15 mins prior to formalin challenge measured after 11 to 45 mins post formalin dosing relative to vehicle-treated control | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature | |
14. | ALA4426171 | T | Toxicity in Kun Ming mouse assessed as decrease in rotarod latency at 40 and 80 mg/kg, ip measured after 60 to 120 mins by rotarod test relative to vehicle-treated control | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature | |
15. | ALA4426172 | A | Permeability of the compound after 18 hrs by PAMPA assay | 7 | ALA4425114 | assay format | Scientific Literature | ||
16. | ALA4426173 | A | Elimination rate constant in Kun Ming mouse plasma at 40 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature | |
17. | ALA4426174 | A | Half life in Kun Ming mouse plasma at 40 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature | |
18. | ALA4426175 | A | Tmax in Kun Ming mouse plasma at 40 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature | |
19. | ALA4426176 | A | Cmax in Kun Ming mouse plasma at 40 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature | |
20. | ALA4426177 | A | AUC (0 to 8 hrs) in Kun Ming mouse plasma at 40 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4425114 | organism-based format | Scientific Literature |