# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4346578 | Binding | Inhibition of human PRMT6 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
2. | ALA4346580 | Binding | Inhibition of PRMT6 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
3. | ALA4346584 | Binding | Covalent binding affinity to human PRMT6 assessed as covalent adduct. formation at 300 uM pre-incubated for 1 hr by mass spectrometry | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
4. | ALA4346589 | Binding | Inhibition of human PRMT1 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
5. | ALA4346590 | Binding | Inhibition of human PRMT3 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
6. | ALA4346591 | Binding | Inhibition of human PRMT4 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
7. | ALA4346592 | Binding | Inhibition of human PRMT8 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
8. | ALA4346599 | Binding | Inhibition of Flag-tagged PRMT6 (unknown origin) expressed in HEK293 cells at 0.1 to 10 uM incubated for 20 hrs assessed as reduction in H3R2me2a levels | Homo sapiens | 2 | ALA4342528 | cell-based format | Scientific Literature | |
9. | ALA4346601 | Binding | Inhibition of PRMT1 in human MCF7 cells assessed as reduction in H4R3me2a levels up to 20 uM incubated for 2 days by fluorescence based assay | Homo sapiens | 1 | ALA4342528 | cell-based format | Scientific Literature | |
10. | ALA4346603 | Binding | Inhibition of PRMT3 (unknown origin) expressed in HEK293T cells were co-transfected with GFP-tagged histone H4 peptide assessed as reduction in H4R3 arginine asymmetric dimethylation at 2.2 to 20 uM incubated for 20 hrs | Homo sapiens | 1 | ALA4342528 | cell-based format | Scientific Literature | |
11. | ALA4346606 | Binding | Inhibition of PRMT4 in human MCF7 cells assessed as reduction in BAF155 asymmetric dimethylation at 2.2 to 20 uM incubated for 2 days | Homo sapiens | 1 | ALA4342528 | cell-based format | Scientific Literature | |
12. | ALA4346608 | Toxicity | Toxicity in human MCF7 cells assessed as reduction in cell viability up to 20 uM incubated for 3 days by CCK8 assay | Homo sapiens | 3 | ALA4342528 | cell-based format | Scientific Literature | |
13. | ALA4346609 | Toxicity | Toxicity in human PNT2 cells assessed as reduction in cell viability up to 20 uM incubated for 3 days by CCK8 assay | Homo sapiens | 3 | ALA4342528 | cell-based format | Scientific Literature | |
14. | ALA4346610 | Toxicity | Toxicity in HEK293T cells assessed as reduction in cell viability up to 20 uM incubated for 3 days by CCK8 assay | Homo sapiens | 3 | ALA4342528 | cell-based format | Scientific Literature | |
15. | ALA4346611 | Binding | Inhibition of PRMT1 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
16. | ALA4346643 | Binding | Inhibition of PRMT1 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 50 uM incubated for 1 hr by scintillation proximity assay relative to control | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
17. | ALA4346646 | Binding | Inhibition of PRMT6 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 50 uM incubated for 1 hr by scintillation proximity assay relative to control | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature |