# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4397500 | F | Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay | Homo sapiens | 43 | ALA4396873 | cell-based format | Scientific Literature | |
2. | ALA4397503 | B | Agonist activity at recombinant human V1B receptor expressed in HEK293 cells measured after 5 hrs by luciferase reporter gene assay | Homo sapiens | 43 | ALA4396873 | cell-based format | Scientific Literature | |
3. | ALA4397506 | B | Selectivity ratio of EC50 for recombinant human V1B receptor expressed in HEK293 cells to EC50 for recombinant human V2 receptor expressed in HEK293 cells | Homo sapiens | 43 | ALA4396873 | cell-based format | Scientific Literature | |
4. | ALA4397507 | A | Agonist activity at recombinant human V1a receptor expressed in HEK293 cells up to 1000 nM measured after 5 hrs by luciferase reporter gene assay | Homo sapiens | 43 | ALA4396873 | cell-based format | Scientific Literature | |
5. | ALA4397508 | A | Clearance in Sprague-Dawley rat at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 43 | ALA4396873 | organism-based format | Scientific Literature | |
6. | ALA4397509 | A | Non-renal clearance in nephrectomized Sprague-Dawley rat at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 43 | ALA4396873 | organism-based format | Scientific Literature | |
7. | ALA4397510 | A | Protein binding in rat plasma at 200 to 1000 ng/ml measured after 15 mins by UC-LC/MS/MS analysis | Rattus norvegicus | 43 | ALA4396873 | cell-free format | Scientific Literature | |
8. | ALA4397511 | B | Agonist activity at human OTR stably expressed in CHOK1 cells up to 10000 nM by NFAT-luciferase reporter gene assay | Homo sapiens | 31 | ALA4396873 | cell-based format | Scientific Literature | |
9. | ALA4397512 | F | Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay | Rattus norvegicus | 3 | ALA4396873 | cell-based format | Scientific Literature | |
10. | ALA4397513 | F | Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay relative to control | Rattus norvegicus | 3 | ALA4396873 | cell-based format | Scientific Literature | |
11. | ALA4397514 | A | Elimination half life in Sprague-Dawley rat at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4396873 | organism-based format | Scientific Literature | |
12. | ALA4397515 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output administered as iv infusion for 180 mins measured during compound dosing | Rattus norvegicus | 2 | ALA4396873 | organism-based format | Scientific Literature | |
13. | ALA4397516 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as effective plasma concentration causing half-maximal suppression of urine output administered as iv infusion for 180 mins measured during compound dosing | Rattus norvegicus | 3 | ALA4396873 | organism-based format | Scientific Literature | |
14. | ALA4397517 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output by measuring cumulative urine weight administered as iv infusion for 180 mins measured during compound dosing | Rattus norvegicus | 3 | ALA4396873 | organism-based format | Scientific Literature | |
15. | ALA4397519 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output by measuring cumulative urine weight at 30 to 100 pM administered as iv infusion for 180 mins measured up to 300 mins | Rattus norvegicus | 2 | ALA4396873 | organism-based format | Scientific Literature | |
16. | ALA4397520 | U | Ratio of EC50 for agonist activity at recombinant rat V2 receptor expressed in HEK293 cells to EC50 for antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as effective plasma concentration causing half-maximal suppression of urine output | 3 | ALA4396873 | cell-based format | Scientific Literature | ||
17. | ALA4397521 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output at MED administered as iv infusion for 180 mins measured during compound dosing relative to control | Rattus norvegicus | 3 | ALA4396873 | organism-based format | Scientific Literature | |
18. | ALA4397523 | A | Half life in iv dosed Sprague-Dawley rat by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4396873 | organism-based format | Scientific Literature | |
19. | ALA4397524 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output at 30 to 100 pM administered as iv infusion for 180 mins measured after 1 hr | Rattus norvegicus | 1 | ALA4396873 | organism-based format | Scientific Literature |