| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4314119 | B | Inhibition of HDAC1/2/3 in human HuH7-luc/neo cells assessed as ratio of H3K9/14ac content to the content of unmodified histone H3 at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 2. | ALA4314120 | B | Inhibition of HDAC1/2/3 in human HuH7-luc/neo cells assessed as ratio of H3K9/14ac content to the content of unmodified histone H3 at 3 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 3. | ALA4314121 | F | Antiviral activity against HCV infected in human HuH7-luc/neo cells assessed as inhibition of viral replicon propagation incubated for 3 days by luciferase reporter gene assay | Hepacivirus hominis | 15 | organism-based format | Scientific Literature | ||
| 4. | ALA4314122 | A | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by MTT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA4314123 | T | Therapeutic index, ratio of CC50 for human HuH7 cells to EC50 for HCV infected in human HuH7-luc/neo cells | 15 | cell-based format | Scientific Literature | |||
| 6. | ALA4314124 | B | Inhibition of HDAC1/2/3 in human HuH7-luc/neo cells assessed as ratio of H3K9/14ac content to the content of unmodified histone H3 at 0.3 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA4314125 | B | Inhibition of HDAC6 in human HuH7-luc/neo cells assessed as ratio of alphaTubK40ac content to the content of unmodified alpha-tubulin at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 8. | ALA4314126 | B | Inhibition of HDAC6 in human HuH7-luc/neo cells assessed as ratio of alphaTubK40ac content to the content of unmodified alpha-tubulin at 3 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 9. | ALA4314128 | B | Inhibition of HDAC8 in human HuH7-luc/neo cells assessed as ratio of SMC3K105/106ac content to the content of unmodified SMC3 at 0.1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4314129 | B | Inhibition of HDAC8 in human HuH7-luc/neo cells assessed as ratio of SMC3K105/106ac content to the content of unmodified SMC3 at 0.3 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4314130 | B | Inhibition of HDAC8 in human HuH7-luc/neo cells assessed as ratio of SMC3K105/106ac content to the content of unmodified SMC3 at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4314131 | B | Inhibition of HDAC8 in human HuH7-luc/neo cells assessed as ratio of SMC3K105/106ac content to the content of unmodified SMC3 at 3 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 13. | ALA4314132 | B | Inhibition of HDAC8 in human HuH7-luc/neo cells assessed as ratio of SMC3K105/106ac content to the content of unmodified SMC3 at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature |
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