| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4387890 | B | Inhibition of MAPK/NFkappaB in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced TNFalpha production at 10 uM pretreated for 0.5 hrs followed by LPS challenge and measured after 24 hrs by ELISA relative to control | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 2. | ALA4387892 | B | Inhibition of MAPK/NFkappaB in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced IL6 production at 10 uM pretreated for 0.5 hrs followed by LPS challenge and measured after 24 hrs by ELISA relative to control | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 3. | ALA4387894 | A | Cytotoxicity against ICR mouse RAW264.7 cells assessed as effect on cell proliferation at 10 uM after 24 hrs by MTT assay | Mus musculus | 31 | cell-based format | Scientific Literature | ||
| 4. | ALA4387895 | B | Inhibition of MAPK/NFkappaB in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced TNFalpha production pretreated for 0.5 hrs followed by LPS challenge and measured after 24 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4387896 | P | Stability in pH 7.4 phosphate buffer assessed as compound decomposition measured up to 25 mins by UV-Vis spectroscopy | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4387897 | A | Oral bioavailability in Sprague-Dawley rat at 50 mg/kg measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4387899 | B | Inhibition of LPS-induced p38 MAPK phosphorylation in ICR mouse RAW264.7 cells at 10 uM preincubated for 0.5 hrs followed by LPS challenge and measured after 30 mins by immunoblotting analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4387900 | B | Inhibition of LPS-induced ERK phosphorylation in ICR mouse RAW264.7 cells at 10 uM preincubated for 0.5 hrs followed by LPS challenge and measured after 30 mins by immunoblotting analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4387901 | B | Inhibition of NFkappaB/MAPK signaling in LPS-induced mouse RAW264.7 cells assessed as down regulation of IkappaB expression at 10 uM preincubated for 0.5 hrs followed by LPS-challenge and measured after 30 mins by immunoblotting analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4387902 | B | Inhibition of LPS-induced NFkappaB p65 nuclear translocation in ICR mouse RAW264.7 cells preincubated for 0.5 hrs followed by LPS challenge and measured after 40 mins by DAPI staining-based immunofluorescence microscopic analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4387903 | B | Inhibition of MAPK/NFkappaB in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced IL6 production pretreated for 0.5 hrs followed by LPS challenge and measured after 24 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4387904 | B | Inhibition of MAPK/NFkappaB signaling in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha mRNA expression pretreated for 0.5 hrs followed by LPS challenge and measured after 40 mins by TRIZOL reagent-based RT-qPCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4387905 | B | Inhibition of MAPK/NFkappaB signaling in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 mRNA expression pretreated for 0.5 hrs followed by LPS challenge and measured after 40 mins by TRIZOL reagent-based RT-qPCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4387906 | B | Inhibition of MAPK/NFkappaB signaling in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced IL1beta mRNA expression pretreated for 0.5 hrs followed by LPS challenge and measured after 40 mins by TRIZOL reagent-based RT-qPCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4387907 | B | Inhibition of MAPK/NFkappaB signaling in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced ICAM1 mRNA expression pretreated for 0.5 hrs followed by LPS challenge and measured after 40 mins by TRIZOL reagent-based RT-qPCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4387908 | B | Inhibition of MAPK/NFkappaB signaling in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced VCAM1 mRNA expression pretreated for 0.5 hrs followed by LPS challenge and measured after 40 mins by TRIZOL reagent-based RT-qPCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4387910 | A | AUC (0 to t) in Sprague-Dawley rat at 50 mg/kg, po by UHPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4387911 | A | AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, iv by UHPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4387912 | A | AUC (0 to infinity) in Sprague-Dawley rat at 50 mg/kg, po by UHPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4387913 | A | AUC (0 to infinity) in Sprague-Dawley rat at 5 mg/kg, iv by UHPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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