# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4336640 | Binding | Inhibition of Influenza A virus (A/WSN/1933(H1N1)) CEN using m7G[5']-ppp-[5'] [m2'-O]GAA UAU(-Cy3) GCA UCA CUA GUA AGC UUU GCU CUA(-BHQ2)-3' as substrate measured after 60 mins by fluorescence assay | Influenza A virus (A/WSN/1933(H1N1)) | 24 | ALA4334467 | single protein format | Scientific Literature | |
2. | ALA4336643 | Functional | Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza A virus | 24 | ALA4334467 | organism-based format | Scientific Literature | |
3. | ALA4336644 | ADME | Metabolic stability in Crj:CD(SD) rat liver microsomes assessed as compound remaining at 2 uM incubated for 30 mins by LC/MS/MS analysis | Rattus norvegicus | 7 | ALA4334467 | microsome format | Scientific Literature | |
4. | ALA4336645 | ADME | In vivo total clearance in Sprague-Dawley rat at 0.5 mg/kg, iv administered as single dose after 2 to 360 mins by LC/MS/MS analysis | Rattus norvegicus | 7 | ALA4334467 | organism-based format | Scientific Literature | |
5. | ALA4336646 | ADME | Protein binding in rat serum assessed as unbound fraction after 24 hrs by LC-MS based equilibrium dialysis analysis | Rattus norvegicus | 7 | ALA4334467 | cell-free format | Scientific Literature | |
6. | ALA4336647 | Functional | Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza A virus | 2 | ALA4334467 | organism-based format | Scientific Literature | |
7. | ALA4336648 | Functional | Antiviral activity against reverse genetic Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza A virus | 2 | ALA4334467 | organism-based format | Scientific Literature | |
8. | ALA4336649 | Functional | Antiviral activity against reverse genetic Influenza A virus (A/WSN/33(H1N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza A virus | 2 | ALA4334467 | organism-based format | Scientific Literature | |
9. | ALA4336650 | Functional | Antiviral activity against Influenza A virus (A/Victoria/3/75(H3N2)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza A virus H3N2 | 2 | ALA4334467 | organism-based format | Scientific Literature | |
10. | ALA4336651 | Functional | Antiviral activity against Influenza A virus H3N2 A/Hong Kong/8/68 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza A virus H3N2 | 2 | ALA4334467 | organism-based format | Scientific Literature | |
11. | ALA4336652 | Functional | Antiviral activity against Influenza B virus (B/Hong Kong/05/72) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza B virus | 2 | ALA4334467 | organism-based format | Scientific Literature | |
12. | ALA4336653 | Functional | Antiviral activity against Influenza B virus (B/Maryland/1/59) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by WST assay | Influenza B virus | 2 | ALA4334467 | organism-based format | Scientific Literature |