# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4314255 | Binding | Disaggregation of Cu2+ induced preformed fibrils of amyloid beta (1 to 42) at 25 uM preincubated with Cu2+ for 24 hrs followed by compound addition and measured after 24 hrs by thioflavin-T based fluorescence assay relative to control | 18 | ALA4311983 | assay format | Scientific Literature | ||
2. | ALA4314256 | Binding | Inhibition of Cu2+-induced amyloid beta (1 to 42 residues) aggregation at 25 uM after 24 hrs by thioflavin T-based fluorescence assay relative to control | 18 | ALA4311983 | assay format | Scientific Literature | ||
3. | ALA4314257 | Binding | Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) self aggregation at 25 uM after 24 hrs by ThT-based fluorescence method relative to control | Homo sapiens | 18 | ALA4311983 | single protein format | Scientific Literature | |
4. | ALA4314259 | Functional | Antioxidant activity assessed as trolox equivalent of AAPH-induced radical scavenging activity preincubated for 15 mins followed by AAPH addition measured every minute for 120 mins by ORAC fluorescein assay | 18 | ALA4311983 | assay format | Scientific Literature | ||
5. | ALA4314263 | Binding | Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells at 10 uM using kynuramine as substrate after 30 mins by fluorescence based assay relative to control | Homo sapiens | 16 | ALA4311983 | cell-based format | Scientific Literature | |
6. | ALA4314265 | Binding | Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence based assay | Homo sapiens | 21 | ALA4311983 | cell-based format | Scientific Literature | |
7. | ALA4314266 | Binding | Selectivity index, ratio of IC50 for equine BuChE to IC50 for electric eel AChE | 15 | ALA4311983 | assay format | Scientific Literature | ||
8. | ALA4314268 | Binding | Inhibition of equine butyrylcholinesterase using butyrylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | Equus caballus | 17 | ALA4311983 | single protein format | Scientific Literature | |
9. | ALA4314269 | ADME | Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | Electrophorus electricus | 21 | ALA4311983 | single protein format | Scientific Literature |