# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4375674 | P | Half life in 0.1 M HCl at 5 mM by HPLC analysis | 6 | ALA4373712 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4375675 | P | Half life in pH 4.5 acetate buffer at 5 mM by HPLC analysis | 6 | ALA4373712 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4375676 | P | Half life in pH 5.8 phosphate buffer at 5 mM by HPLC analysis | 6 | ALA4373712 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4375677 | P | Half life in pH 6.8 phosphate buffer at 5 mM by HPLC analysis | 6 | ALA4373712 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4375678 | P | Half life in pH 7.2 phosphate buffer at 5 mM by HPLC analysis | 6 | ALA4373712 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4375679 | A | Half life in pH 1.2 simulated gastric fluid at 5 mM by HPLC analysis | 6 | ALA4373712 | assay format | Scientific Literature | ||
7. | ALA4375680 | A | Half life in pH 6.8 simulated intestinal fluid at 5 mM by HPLC analysis | 6 | ALA4373712 | assay format | Scientific Literature | ||
8. | ALA4375681 | A | Half life in Sprague-Dawley rat intestinal homogenates at 5 mM by HPLC analysis | Rattus norvegicus | 6 | ALA4373712 | tissue-based format | Scientific Literature | |
9. | ALA4375682 | A | Half life in Sprague-Dawley rat liver homogenates at 5 mM by HPLC analysis | Rattus norvegicus | 6 | ALA4373712 | tissue-based format | Scientific Literature | |
10. | ALA4375683 | A | Half life in Sprague-Dawley rat plasma at 5 mM by HPLC analysis | Rattus norvegicus | 6 | ALA4373712 | cell-free format | Scientific Literature | |
11. | ALA4375684 | A | Ratio of half-life in pH 7.2 phosphate buffer to half-life in Sprague-Dawley rat intestinal homogenates | 5 | ALA4373712 | tissue-based format | Scientific Literature | ||
12. | ALA4375685 | A | Ratio of half-life in pH 7.2 phosphate buffer to half-life in Sprague-Dawley rat liver homogenates | 5 | ALA4373712 | tissue-based format | Scientific Literature | ||
13. | ALA4375686 | A | Ratio of half-life in pH 7.2 phosphate buffer to half-life in Sprague-Dawley rat plasma | 5 | ALA4373712 | assay format | Scientific Literature | ||
14. | ALA4375687 | A | Apparent permeability across human Caco2 cells at 0.5 mM measured after 5 to 60 mins by UPLC-MS/MS analysis | Homo sapiens | 6 | ALA4373712 | cell-based format | Scientific Literature | |
15. | ALA4375690 | A | Substrate activity at PEPT1 in Sprague-Dawley rat jejunum assessed as effective permeability at 5 mM measured after 15 to 120 mins by HPLC analysis | Rattus norvegicus | 3 | ALA4373712 | tissue-based format | Scientific Literature | |
16. | ALA4375691 | A | Ratio of test compound effect to JBP485 effect for substrate activity at PEPT1 in Sprague-Dawley rat jejunum assessed as effective permeability | Rattus norvegicus | 1 | ALA4373712 | tissue-based format | Scientific Literature | |
17. | ALA4375692 | A | Ratio of compound effect for substrate activity at PEPT1 in Sprague-Dawley rat jejunum assessed as effective permeability in absence of non-metabolized PEPT1 substrate Gly-Sar to compound effect for substrate activity at PEPT1 in Sprague-Dawley rat jejunum assessed as effective permeability in presence of non-metabolized PEPT1 substrate Gly-Sar | Rattus norvegicus | 3 | ALA4373712 | single protein format | Scientific Literature | |
18. | ALA4375693 | A | Substrate activity at PEPT1 in human Caco2 cells assessed as protein-mediated drug uptake at 0.5 mM measured after 10 mins in pH 6 HBSS buffer by UPLC-MS/MS analysis | Homo sapiens | 3 | ALA4373712 | cell-based format | Scientific Literature | |
19. | ALA4375694 | A | Substrate activity at PEPT1 in human Caco2 cells assessed as protein-mediated drug uptake at 0.5 mM measured after 10 mins in pH 7.4 HBSS buffer by UPLC-MS/MS analysis | Homo sapiens | 3 | ALA4373712 | cell-based format | Scientific Literature | |
20. | ALA4375695 | A | Substrate activity at PEPT1 in human Caco2 cells assessed as protein-mediated drug uptake at 0.5 mM measured after 10 mins in pH 6 HBSS buffer in presence of non-metabolized PEPT1 substrate Gly-Sar by UPLC-MS/MS analysis | Homo sapiens | 3 | ALA4373712 | cell-based format | Scientific Literature |