| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4412720 | Binding | Inhibition of SMS2 (unknown origin) over-expressed in H5 insect cell lysate using C6-NBD-Ceramide and DMPC as substrates preincubated for 30 mins followed by substrate addition and measured after 2 hrs by TLC or HPLC method | Homo sapiens | 39 | ALA4411297 | subcellular format | Scientific Literature | |
| 2. | ALA4412721 | Binding | Inhibition of purified SMS2 (unknown origin) using C6-NBD-Ceramide and DMPC as substrates preincubated for 5 mins followed by substrate addition and measured after 30 mins by TLC or HPLC method | Homo sapiens | 2 | ALA4411297 | single protein format | Scientific Literature | |
| 3. | ALA4412722 | Binding | Inhibition of purified SMS1 (unknown origin) using C6-NBD-Ceramide and DMPC as substrates preincubated for 5 mins followed by substrate addition and measured after 30 mins by TLC or HPLC method | Homo sapiens | 1 | ALA4411297 | single protein format | Scientific Literature | |
| 4. | ALA4412723 | Binding | Selectivity ratio of IC50 for purified SMS1 (unknown origin) to IC50 for purified SMS2 (unknown origin) | Homo sapiens | 1 | ALA4411297 | assay format | Scientific Literature | |
| 5. | ALA4412724 | Binding | Inhibition of SMS2 in human HuH7 cells assessed as down regulation of apoB secretion incubated for 17 hrs followed by further incubation for 2 hrs in presence of [35S]-methionine | Homo sapiens | 1 | ALA4411297 | cell-based format | Scientific Literature | |
| 6. | ALA4412725 | Binding | Inhibition of SMS2 in C57BL/6J mouse bone marrow derived macrophages assessed as increase in [3H]-cholesterol efflux after 17 hrs by liquid scintillation analysis | Mus musculus | 1 | ALA4411297 | single protein format | Scientific Literature | |
| 7. | ALA4412726 | Functional | Inhibition of LPS-induced IL-6 secretion in C57BL/6J mouse bone marrow derived macrophages preincubated for 17 hrs followed by LPS-stimulation and measured after 6 hrs by ELISA | Mus musculus | 1 | ALA4411297 | cell-based format | Scientific Literature | |
| 8. | ALA4412727 | Functional | Induction of cytosolic IkappaBalpha secretion in LPS-stimulated C57BL/6J mouse bone marrow derived macrophages preincubated for 17 hrs followed by LPS-stimulation and measured after 6 hrs by Western blot analysis | Mus musculus | 1 | ALA4411297 | cell-based format | Scientific Literature | |
| 9. | ALA4412728 | Functional | Inhibition of LPS-induced MCP1 production in C57BL/6J mouse bone marrow derived macrophages at 6.25 to 50 uM preincubated for 17 hrs followed by LPS-stimulation and measured after 6 hrs by ELISA | Mus musculus | 1 | ALA4411297 | cell-based format | Scientific Literature | |
| 10. | ALA4412729 | ADME | AUC (0 to 8 hrs) in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 11. | ALA4412730 | ADME | Dose normalized AUC (0 to 8 hrs) in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 12. | ALA4412731 | ADME | AUC (0 to infinity) in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 13. | ALA4412732 | ADME | Tmax in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 14. | ALA4412733 | ADME | Cmax in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 15. | ALA4412734 | ADME | Half life in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 16. | ALA4412735 | ADME | Apparent volume of distribution during terminal phase in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 17. | ALA4412736 | ADME | Apparent oral clearance in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 18. | ALA4412737 | ADME | MRT (0 to 8 hrs) in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 19. | ALA4412738 | ADME | MRT (0 to infinity) in C57BL/6J mouse at 100 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature | |
| 20. | ALA4412739 | ADME | AUC (0 to 8 hrs) in C57BL/6J mouse at 50 mg/kg/day, ig by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4411297 | organism-based format | Scientific Literature |
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