#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4396778	Binding	Inhibition of human chymotrypsin-like activity of 20S proteasome using Suc-LLVY-AMC as substrate pre-incubated for 10 mins followed by substrate addition and measured after 1 hr by spectrofluorimetry	Homo sapiens	32	ALA4393740	single protein format	Scientific Literature
2.	ALA4396779	ADME	Half life in rat liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Rattus norvegicus	2	ALA4393740	microsome format	Scientific Literature
3.	ALA4396780	ADME	Half life in monkey liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Macaca mulatta	2	ALA4393740	microsome format	Scientific Literature
4.	ALA4396781	ADME	Half life in BALB/c mouse liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Mus musculus	2	ALA4393740	microsome format	Scientific Literature
5.	ALA4396782	ADME	Half life in dog liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Canis lupus familiaris	2	ALA4393740	microsome format	Scientific Literature
6.	ALA4396783	ADME	Half life in human liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Homo sapiens	2	ALA4393740	microsome format	Scientific Literature
7.	ALA4396784	ADME	Intrinsic clearance in rat liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Rattus norvegicus	2	ALA4393740	microsome format	Scientific Literature
8.	ALA4396785	ADME	Intrinsic clearance in BALB/c mouse liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Mus musculus	2	ALA4393740	microsome format	Scientific Literature
9.	ALA4396786	ADME	Intrinsic clearance in dog liver microsomes at 1 uM pre-incubated for 5 mins followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Canis lupus familiaris	2	ALA4393740	microsome format	Scientific Literature
10.	ALA4396787	ADME	Intrinsic clearance in monkey liver microsomes at 1 uM pre-incubated for 5 min followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Macaca mulatta	2	ALA4393740	microsome format	Scientific Literature
11.	ALA4396788	ADME	Intrinsic clearance in human liver microsomes at 1 uM pre-incubated for 5 min followed by NADP+ addition and measured up to 20 mins by LC-MS analysis	Homo sapiens	2	ALA4393740	microsome format	Scientific Literature
12.	ALA4396789	Functional	Antitumour activity against luciferase expressing human RPMI8226 cells xenografted in NOD/SCID mouse assessed as tumor growth at 2 mg/kg, iv qd for 21 days by caliper method relative to control	Homo sapiens	1	ALA4393740	organism-based format	Scientific Literature
13.	ALA4396790	Functional	Antitumour activity against human ARH77 cells xenografted in nude mouse assessed as tumor growth at 5mg/kg, iv dosed at day 1 ,4, 8 ,11, 15 and 18 for 3 weeks and measured every 2 days by caliper method relative to control	Homo sapiens	2	ALA4393740	organism-based format	Scientific Literature
14.	ALA4396791	Functional	Cytotoxicity against human RPMI8226 cells assessed as cell viability measured after 72 hrs by celltiter96 aqueous cell proliferation assay	Homo sapiens	8	ALA4393740	cell-based format	Scientific Literature
15.	ALA4396792	Functional	Cytotoxicity against human U266B1 cells assessed as cell viability measured after 72 hrs by celltiter96 aqueous cell proliferation assay	Homo sapiens	8	ALA4393740	cell-based format	Scientific Literature
16.	ALA4396793	Binding	Inhibition of human ERG in HEK293 cells assessed as effect on QT interval	Homo sapiens	2	ALA4393740	cell-based format	Scientific Literature
17.	ALA4396794	ADME	Potency index, ratio of compound half life in human liver microsomes to carfilzomib half life in human liver microsomes	Homo sapiens	1	ALA4393740	microsome format	Scientific Literature