# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4357465 | Functional | Antagonist activity at human melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis | Homo sapiens | 8 | ALA4354837 | cell-based format | Scientific Literature | |
2. | ALA4357466 | Functional | Inverse agonist activity at human melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of basal cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay | Homo sapiens | 9 | ALA4354837 | cell-based format | Scientific Literature | |
3. | ALA4357467 | Functional | Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay | Mus musculus | 3 | ALA4354837 | cell-based format | Scientific Literature | |
4. | ALA4357470 | Functional | Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation at 100 uM incubated for 2 hrs by cAMP Alpha-screen assay relative to control | Mus musculus | 2 | ALA4354837 | cell-based format | Scientific Literature | |
5. | ALA4357471 | Functional | Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis | Mus musculus | 8 | ALA4354837 | cell-based format | Scientific Literature | |
6. | ALA4357473 | Functional | Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation at 100 uM incubated for 2 hrs by cAMP Alpha-screen assay relative to control | Mus musculus | 3 | ALA4354837 | cell-based format | Scientific Literature | |
7. | ALA4357474 | Functional | Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis | Mus musculus | 8 | ALA4354837 | cell-based format | Scientific Literature | |
8. | ALA4357475 | Functional | Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay | Mus musculus | 7 | ALA4354837 | cell-based format | Scientific Literature | |
9. | ALA4357478 | Functional | Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis | Mus musculus | 10 | ALA4354837 | cell-based format | Scientific Literature | |
10. | ALA4357479 | Binding | Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Mus musculus | 11 | ALA4354837 | cell-based format | Scientific Literature | |
11. | ALA4357481 | Binding | Ratio of IC50 for MDE6-82-1c to IC50 for test compound for displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Mus musculus | 4 | ALA4354837 | assay format | Scientific Literature | |
12. | ALA4357482 | Binding | Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Mus musculus | 11 | ALA4354837 | cell-based format | Scientific Literature | |
13. | ALA4357484 | Binding | Ratio of IC50 for MDE6-82-1c to IC50 for test compound for displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Mus musculus | 4 | ALA4354837 | assay format | Scientific Literature | |
14. | ALA4357485 | Binding | Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Mus musculus | 11 | ALA4354837 | cell-based format | Scientific Literature | |
15. | ALA4357487 | Binding | Ratio of IC50 for MDE6-82-1c to IC50 for test compound for displacement of [125I]-NDP-MSH from mouse melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Mus musculus | 4 | ALA4354837 | assay format | Scientific Literature | |
16. | ALA4357488 | Binding | Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Mus musculus | 11 | ALA4354837 | cell-based format | Scientific Literature | |
17. | ALA4357491 | Binding | Displacement of [125I]-NDP-MSH from human melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method | Homo sapiens | 11 | ALA4354837 | cell-based format | Scientific Literature | |
18. | ALA4357493 | Binding | Ratio of IC50 for MDE6-82-1c to IC50 for test compound for displacement of [125I]-NDP-MSH from human melanocortin receptor 4 expressed in HEK293 cell membranes incubated for 1 hr by automatic gamma counting method | Homo sapiens | 4 | ALA4354837 | cell-based format | Scientific Literature |
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