# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4354696 | B | Inhibition of ABCG2-mediated mitoxantrone efflux in human NCI-H460/MX20 cells assessed as increase in accumulation of [3H]MX at 10 uM incubated for 2 hrs followed by [3H]MX addition and measured after 2 hrs by liquid scintillation counter | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4354704 | A | Cytotoxicity against human NCI-H460 cells assessed as concentration that causes inhibition of cell viability by <=20% incubated for 24 hrs by MTT assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
3. | ALA4354705 | A | Cytotoxicity against human NCI-H460/MX20 cells assessed as concentration that causes inhibition of cell viability by <=20% incubated for 24 hrs by MTT assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
4. | ALA4354708 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 10 to 25 uM pretreated with compound for 2 hrs followed by mitoxantrone challenge for 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4354709 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity by measuring inhibition of cell proliferation at 25 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay (Rvb = 24 +/- 3%) | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
6. | ALA4354710 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity by measuring inhibition of cell proliferation pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
7. | ALA4354711 | A | Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4354712 | A | Cytotoxicity against human NCI-H460/MX20 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4354713 | A | Cytotoxicity against human S1 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4354714 | A | Cytotoxicity against human S1-M1-80 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4354715 | A | Cytotoxicity against HEK293 cells transfected with pcDNA3.1 assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA4354716 | A | Cytotoxicity against HEK293 cells expressing wild type ABCG2-482-R2 assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4354717 | A | Cytotoxicity against HEK293 cells harbouring ABCG2-482-G2 mutant assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4354718 | A | Cytotoxicity against HEK293 cells harbouring ABCG2-482-T7 mutant assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4354719 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of cisplatin-induced cytotoxicity at 25 uM pretreated for 2 hrs followed by cisplatin addition and measured after 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4354720 | B | Reversal of ABCG2-mediated multidrug resistance in human S1-M1-80 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 25 uM pretreated with compound for 2 hrs followed by mitoxantrone challenge for 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4354721 | B | Reversal of ABCG2-mediated multidrug resistance in human S1-M1-80 cells assessed as potentiation of doxorubicin-induced cytotoxicity at 25 uM pretreated with compound for 2 hrs followed by doxorubicin challenge for 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4354722 | B | Reversal of ABCG2 (unknown origin) expressed in HEK293 cells-mediated multidrug resistance assessed as potentiation of mitoxantrone-induced cytotoxicity at 10 to 25 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4354723 | B | Reversal of ABCG2 482-G2 mutant (unknown oirigin) expressed in HEK293 cells-mediated multidrug resistance assessed as potentiation of mitoxantrone-induced cytotoxicity at 10 to 25 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA4354724 | B | Reversal of ABCG2 482-T7 mutant (unknown origin) expressed in HEK293 cells-mediated multidrug resistance assessed as potentiation of mitoxantrone-induced cytotoxicity at 10 to 25 uM pretreated for 2 hrs followed by mitoxantrone challenge and measured after 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature |