# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4385509 | F | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in mouse 3T3 cells after 6 days by beta galactosidase reporter assay | Trypanosoma cruzi | 31 | ALA4382293 | organism-based format | Scientific Literature | |
2. | ALA4385510 | F | Antitrypanosomal activity against Trypanosoma brucei BF427 after 48 hrs by Alamar Blue assay | Trypanosoma brucei | 31 | ALA4382293 | organism-based format | Scientific Literature | |
3. | ALA4385511 | A | Cytotoxicity against human CRL8155 cells after 48 hrs by alamar blue assay | Homo sapiens | 31 | ALA4382293 | cell-based format | Scientific Literature | |
4. | ALA4385512 | A | Cytotoxicity against human HepG2 cells after 48 hrs by alamar blue assay | Homo sapiens | 31 | ALA4382293 | cell-based format | Scientific Literature | |
5. | ALA4385518 | A | Half life in human liver microsomes by LC/MS analysis | Homo sapiens | 22 | ALA4382293 | microsome format | Scientific Literature | |
6. | ALA4385519 | A | Half life in mouse liver microsomes by LC/MS analysis | Mus musculus | 22 | ALA4382293 | microsome format | Scientific Literature | |
7. | ALA4385520 | A | Cmax in Swiss Webster mouse at 50 mg/kg, po administered as single dose via gavage by LC/MS analysis | Mus musculus | 16 | ALA4382293 | organism-based format | Scientific Literature | |
8. | ALA4385521 | A | AUC in Swiss Webster mouse at 50 mg/kg, po administered as single dose via gavage by LC/MS analysis | Mus musculus | 16 | ALA4382293 | organism-based format | Scientific Literature | |
9. | ALA4385522 | P | Solubility of the compound in 7% tween80/5% DMSO/3% ethanol/0.9% saline | 1 | ALA4382293 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4385527 | P | Solubility of the compound in pH 7.4 phosphate buffered saline at 50 uM after overnight incubation by LC-MS analysis | 15 | ALA4382293 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4385528 | P | Solubility of the compound in pH 6.5 phosphate buffered saline at 50 uM after overnight incubation by LC-MS analysis | 15 | ALA4382293 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4385529 | P | Solubility of the compound in pH 2 0.01M HCl at 50 uM after overnight incubation by LC-MS analysis | 15 | ALA4382293 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4385530 | A | Protein binding in 50% pooled CD-1 mouse plasma assessed as unbound fraction at 2 uM after overnight incubation by LC/MS analysis | Mus musculus | 14 | ALA4382293 | cell-free format | Scientific Literature | |
14. | ALA4385531 | A | Ratio of drug level in brain to plasma in Swiss Webster mouse at 5 mg/kg, ip measured after 1 hr by LC/MS analysis | Mus musculus | 12 | ALA4382293 | organism-based format | Scientific Literature | |
15. | ALA4385537 | F | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in Balb/c mouse assessed as parasite infection at 50 mg/kg, po administered twice daily for 5 days starting from day 7 post-infection measured on day 13, 17, 24 and 42 | Trypanosoma cruzi | 1 | ALA4382293 | organism-based format | Scientific Literature | |
16. | ALA4385539 | F | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in Balb/c mouse assessed as cured mouse at 50 mg/kg, po administered twice daily for 5 days starting from day 7 post-infection measured on day 65 | Trypanosoma cruzi | 1 | ALA4382293 | organism-based format | Scientific Literature | |
17. | ALA4385540 | F | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in Balb/c mouse assessed as survival rate at 50 mg/kg, po administered twice daily for 5 days starting from day 7 post-infection measured on day 65 relative to control | Trypanosoma cruzi | 2 | ALA4382293 | organism-based format | Scientific Literature | |
18. | ALA4385543 | T | Toxicity in Balb/c mouse infected with Trypanosoma cruzi Tulahuen amastigotes assessed as body weight loss at 50 mg/kg, po administered twice daily for 5 days starting from day 7 post-infection | Mus musculus | 2 | ALA4382293 | organism-based format | Scientific Literature | |
19. | ALA4481161 | F | Antileishmanial activity against Leishmania donovani MHOM/SD/62/1S-CL2D axenic amastigote after 48 hrs by CellTiter-Glo luminescent cell viability assay | Leishmania donovani | 4 | ALA4480398 | organism-based format | Scientific Literature | |
20. | ALA4481162 | F | Antibacterial activity against Trypanosoma brucei Lister 427 bloodstream form after 48 hrs by CellTiter-Glo luminescent cell viability assay | Trypanosoma brucei | 4 | ALA4480398 | organism-based format | Scientific Literature |