# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4411044 | T | Toxicity in BALB/c mouse xenografted with mouse 4T1 cells assessed as change in serum creatinine level at 10 mg/kg administered intratumorally and measured after 24 days | Mus musculus | 4 | ALA4406918 | organism-based format | Scientific Literature | |
2. | ALA4411045 | T | Toxicity in BALB/c mouse xenografted with mouse 4T1 cells assessed as change in blood urea nitrogen level at 10 mg/kg administered intratumorally and measured after 24 days | Mus musculus | 4 | ALA4406918 | organism-based format | Scientific Literature | |
3. | ALA4411046 | F | Antitumour activity against mouse 4T1 cells xenografted in BALB/c mouse assessed as increase in damage of tumor tissue at 10 mg/kg administered intratumorally and measured after 24 days by H and E staining based inverted optical microscopic method | Mus musculus | 4 | ALA4406918 | organism-based format | Scientific Literature | |
4. | ALA4411049 | A | Stability in fetal bovine serum assessed as parent compound remaining measured after 12 hrs by RP-HPLC analysis | Bos taurus | 3 | ALA4406918 | cell-free format | Scientific Literature | |
5. | ALA4411050 | F | Antiproliferative activity against mouse 4T1 cells at 0.1 mM incubated for 24 hrs by MTT assay | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
6. | ALA4411051 | F | Antiproliferative activity against mouse 4T1 cells assessed as cell death at 0.2 mM incubated for 24 hrs by MTT assay relative to control | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
7. | ALA4411053 | A | Hemolytic activity in BALB/c mouse RBC at 3.2 mM incubated for 2 hrs by UV-Vis spectrophotometric analysis | Mus musculus | 5 | ALA4406918 | cell-based format | Scientific Literature | |
8. | ALA4411054 | F | Induction of apoptosis in mouse 4T1 cells at 0.4 mM incubated for 24 hrs by PI staining based inverted microscopic method | Mus musculus | 1 | ALA4406918 | cell-based format | Scientific Literature | |
9. | ALA4411056 | F | Induction of cell death in mouse 4T1 cells incubated for 24 hrs by PI staining based inverted microscopic method | Mus musculus | 2 | ALA4406918 | cell-based format | Scientific Literature | |
10. | ALA4411057 | F | Induction of cell cycle arrest in mouse 4T1 cells assessed as accumulation at G0/G1 phase at 0.4 mM incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 37.78%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
11. | ALA4411058 | F | Induction of cell cycle arrest in mouse 4T1 cells assessed as accumulation at S phase at 0.4 mM incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb =42.35%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
12. | ALA4411059 | F | Induction of cell cycle arrest in mouse 4T1 cells assessed as accumulation at G2/M phase at 0.4 mM incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 19.82%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
13. | ALA4411063 | F | Induction of apoptosis in mouse 4T1 cells assessed as viable cells at 0.4 mM incubated for 24 hrs by Annexin V-FITC/PI based FACS analysis (Rvb = 92.2%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
14. | ALA4411064 | F | Induction of apoptosis in mouse 4T1 cells assessed as early apoptotic cells at 0.4 mM incubated for 24 hrs by Annexin V-FITC/PI based FACS analysis (Rvb = 0.76%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
15. | ALA4411065 | F | Induction of apoptosis in mouse 4T1 cells assessed as late apoptotic cells at 0.4 mM incubated for 24 hrs by Annexin V-FITC/PI based FACS analysis (Rvb = 6.62%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
16. | ALA4411066 | F | Induction of apoptosis in mouse 4T1 cells assessed as necrotic cells at 0.4 mM incubated for 24 hrs by Annexin V-FITC/PI based FACS analysis (Rvb = 0.47%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
17. | ALA4411071 | F | Inhibition of cell migration in mouse 4T1 cells assessed as wound closure rate at 0.2 mM measured up to 36 hrs by inverted optical microscopic method based wound healing assay (Rvb = 82%) | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
18. | ALA4411073 | F | Inhibition of cell migration in mouse 4T1 cells assessed as migration frequency at 0.2 mM incubated for 24 hrs by crystal violet staining based transwell assay relative to control | Mus musculus | 4 | ALA4406918 | cell-based format | Scientific Literature | |
19. | ALA4411075 | F | Potency index, ratio of test compound effect to YSL effect for inhibition of cell migration in mouse 4T1 cells | Mus musculus | 1 | ALA4406918 | cell-based format | Scientific Literature | |
20. | ALA4411077 | F | Inhibition of metastasis in mouse 4T1 cells assessed as formation of pseudopods at 0.2 mM incubated for 24 hrs by SEM analysis | Mus musculus | 2 | ALA4406918 | cell-based format | Scientific Literature |