# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4428139 | Binding | Activation of full-length GST-tagged recombinant human SIRT1 assessed as enzyme activity obtained without subtraction of intrinsic fluorescence using H3K9 as substrate at 50 uM after 30 mins by SIRTainty assay | Homo sapiens | 56 | ALA4428023 | single protein format | Scientific Literature | |
2. | ALA4428140 | Binding | Activation of full-length GST-tagged recombinant human SIRT1 assessed as enzyme activity obtained with subtraction of intrinsic fluorescence using H3K9 as substrate at 50 uM after 30 mins by SIRTainty assay | Homo sapiens | 51 | ALA4428023 | single protein format | Scientific Literature | |
3. | ALA4428142 | Binding | Activation of AMPK/SIRT1 in human HaCaT cells assessed as nitric oxide production at 1 uM incubated for 1 hr by DAF-2D staining-based fluorescence assay | Homo sapiens | 7 | ALA4428023 | cell-based format | Scientific Literature | |
4. | ALA4428144 | Binding | Activation of AMPK/SIRT1 in human HaCaT cells assessed as nitric oxide production at 10 uM incubated for 1 hr in presence of compound C by DAF-2D staining-based fluorescence assay | Homo sapiens | 3 | ALA4428023 | cell-based format | Scientific Literature | |
5. | ALA4428145 | Binding | Activation of AMPK/SIRT1 in human HaCaT cells assessed as nitric oxide production at 10 uM incubated for 1 hr in presence of EX-527 by DAF-2D staining-based fluorescence assay | Homo sapiens | 3 | ALA4428023 | cell-based format | Scientific Literature | |
6. | ALA4428157 | Functional | Antiproliferative activity against human M14 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
7. | ALA4428158 | Functional | Antiproliferative activity against human SAN cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
8. | ALA4428159 | Functional | Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
9. | ALA4428160 | Functional | Antiproliferative activity against human NCI-H1299 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
10. | ALA4428161 | Functional | Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
11. | ALA4428162 | Functional | Antiproliferative activity against human LoVo cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
12. | ALA4428163 | Functional | Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
13. | ALA4428164 | Functional | Antiproliferative activity against human Caov3 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
14. | ALA4428165 | Functional | Antiproliferative activity against human HEY cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
15. | ALA4428166 | Functional | Antiproliferative activity against human SKOV3 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
16. | ALA4428167 | Functional | Antiproliferative activity against human A2780 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4428023 | cell-based format | Scientific Literature | |
17. | ALA4428168 | Binding | Activation of SIRT1 in human M14 cells assessed as deacetylation of acetyl-H4K16 after 48 hrs by Western blotting method | Homo sapiens | 1 | ALA4428023 | cell-based format | Scientific Literature | |
18. | ALA4428169 | Binding | Activation of SIRT1 in human NCI-H1299 cells assessed as deacetylation of acetyl-H4K16 after 48 hrs by Western blotting method | Homo sapiens | 1 | ALA4428023 | cell-based format | Scientific Literature |