# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4356586 | Binding | Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incubated for 60 mins in presence of 0.05 nM biotin-Bim by HTRF assay | Homo sapiens | 29 | ALA4354823 | single protein format | Scientific Literature | |
2. | ALA4356587 | Binding | Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incubated for 60 mins in presence of 5 nM biotin-Bim by HTRF assay | Homo sapiens | 21 | ALA4354823 | single protein format | Scientific Literature | |
3. | ALA4356588 | Functional | Antiproliferative activity against human OPM2 cells assessed as reduction in cell viability after 16 hrs by CellTiter-Glo based luminescence assay | Homo sapiens | 24 | ALA4354823 | cell-based format | Scientific Literature | |
4. | ALA4356590 | ADME | Stability in simulated gastric fluid assessed as parent compound remaining at 1 uM at pH 1.7 and 37 degree C measured after 30 mins | 3 | ALA4354823 | assay format | Scientific Literature | ||
5. | ALA4356591 | ADME | Stability in simulated gastric fluid assessed as parent compound remaining at 1 uM at pH 1.7 and 37 degree C measured after 60 mins | 3 | ALA4354823 | assay format | Scientific Literature | ||
6. | ALA4356592 | ADME | Stability in simulated intestinal fluid assessed as parent compound remaining at 1 uM at pH 6.6 and 37 degree C measured after 30 mins | 3 | ALA4354823 | assay format | Scientific Literature | ||
7. | ALA4356593 | ADME | Stability in simulated intestinal fluid assessed as parent compound remaining at 1 uM at pH 6.6 and 37 degree C measured after 60 mins | 3 | ALA4354823 | assay format | Scientific Literature | ||
8. | ALA4356596 | ADME | Half life in Sprague-Dawley rat at 0.5 mg/kg, iv | Rattus norvegicus | 14 | ALA4354823 | organism-based format | Scientific Literature | |
9. | ALA4356597 | ADME | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg | Rattus norvegicus | 12 | ALA4354823 | organism-based format | Scientific Literature | |
10. | ALA4356601 | ADME | Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv | Rattus norvegicus | 14 | ALA4354823 | organism-based format | Scientific Literature | |
11. | ALA4356638 | ADME | Apparent permeability in pig LLC-PK1 cells by LC/MS analysis | Sus scrofa | 3 | ALA4354823 | cell-based format | Scientific Literature | |
12. | ALA4356639 | ADME | Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv relative to liver blood flow | Rattus norvegicus | 2 | ALA4354823 | organism-based format | Scientific Literature |