# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4384324 | B | Inhibition of Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression at 5 uM after 24 hrs by q-PCR analysis relative to oxysterol alone | Mus musculus | 16 | ALA4382241 | cell-based format | Scientific Literature | |
2. | ALA4384327 | B | Inhibition of Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis | Mus musculus | 16 | ALA4382241 | cell-based format | Scientific Literature | |
3. | ALA4384328 | B | Activation of VDR in mouse C3H10T1/2 cells assessed as change in Cyp24A1 mRNA expression at 5 uM after 24 hrs by q-PCR analysis relative to control | Mus musculus | 18 | ALA4382241 | cell-based format | Scientific Literature | |
4. | ALA4384330 | B | Inhibition of Hedgehog signaling pathway in mouse ASZ001 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 48 hrs by q-PCR analysis | Mus musculus | 15 | ALA4382241 | cell-based format | Scientific Literature | |
5. | ALA4384332 | B | Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression at 2.5 uM after 48 hrs by q-PCR analysis relative to control | Mus musculus | 2 | ALA4382241 | cell-based format | Scientific Literature | |
6. | ALA4384335 | F | Antiproliferative activity against medulloblastoma cells derived from conditional patched knockout mouse after 48 hrs by [3H]-thymidine incorporation assay | Mus musculus | 9 | ALA4382241 | cell-based format | Scientific Literature | |
7. | ALA4384336 | A | Half life in human liver microsomes at 1 uM by LC-MS/MS analysis | Homo sapiens | 10 | ALA4382241 | microsome format | Scientific Literature | |
8. | ALA4384337 | A | Clearance in human liver microsomes assessed per mg protein at 1 uM by LC-MS/MS analysis | Homo sapiens | 11 | ALA4382241 | microsome format | Scientific Literature | |
9. | ALA4384338 | P | Kinetic solubility of the compound in pH 4 phosphate buffered saline | 11 | ALA4382241 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4384339 | P | Kinetic solubility of the compound in pH 7.4 phosphate buffered saline | 11 | ALA4382241 | small-molecule physicochemical format | Scientific Literature |