# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4428708 | B | Inhibition of polyHis tagged full length recombinant PI3Kdelta (unknown origin) expressed in Sf9 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | ALA4428047 | cell-based format | Scientific Literature | |
2. | ALA4428709 | B | Inhibition of polyHis tagged full length recombinant PI3Kalpha (unknown origin) expressed in Sf9 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | ALA4428047 | cell-based format | Scientific Literature | |
3. | ALA4428710 | B | Inhibition of polyHis tagged full length recombinant PI3Kbeta (unknown origin) expressed in Sf9 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | ALA4428047 | cell-based format | Scientific Literature | |
4. | ALA4428711 | B | Inhibition of N-terminal polyHis tagged full length recombinant PI3Kgamma (114 to 1102 residues) (unknown origin) expressed in Hi5 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | ALA4428047 | cell-based format | Scientific Literature | |
5. | ALA4428712 | F | Inhibition of cell proliferation of human B cells pre-incubated for 30 mins before anti-IgM/CD40L stimulation and measured after 72 hrs by [3H]thymidine incorporation assay | Homo sapiens | 17 | ALA4428047 | cell-based format | Scientific Literature | |
6. | ALA4428713 | B | Inhibition of PI3Kdelta in BALB/c mouse B cells assessed as reduction in Anti-IgM induced AKT Ser473 phosphorylation pre-incubated for 45 mins before Anti-IgM stimulation | Mus musculus | 17 | ALA4428047 | cell-based format | Scientific Literature | |
7. | ALA4428714 | A | Clearance in rat liver microsomes assessed as drug turnover level at 1 uM incubated for 30 mins in presence of NADPH | Rattus norvegicus | 17 | ALA4428047 | microsome format | Scientific Literature | |
8. | ALA4428715 | A | Clearance in human liver microsomes assessed as drug turnover level at 1 uM incubated for 30 mins in presence of NADPH | Homo sapiens | 17 | ALA4428047 | microsome format | Scientific Literature | |
9. | ALA4428716 | A | Inhibition of CYP3A4 (unknown origin) at 3 uM using midazolam substrate by LC-MS method | Homo sapiens | 17 | ALA4428047 | single protein format | Scientific Literature | |
10. | ALA4428717 | A | Inhibition of CYP2D6 (unknown origin) at 3 uM using midazolam substrate by LC-MS method | Homo sapiens | 17 | ALA4428047 | single protein format | Scientific Literature | |
11. | ALA4428718 | A | Activation of human PXR assessed as remaining activity at 2 uM relative to untreated control | Homo sapiens | 17 | ALA4428047 | single protein format | Scientific Literature | |
12. | ALA4428719 | A | Activation of human PXR assessed as remaining activity at 10 uM relative to untreated control | Homo sapiens | 17 | ALA4428047 | single protein format | Scientific Literature | |
13. | ALA4428720 | A | Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv by by LC-MS method | Rattus norvegicus | 17 | ALA4428047 | organism-based format | Scientific Literature | |
14. | ALA4428721 | A | Unbound clearance in Sprague-Dawley rat at 0.5 mg/kg, iv by by LC-MS method | Rattus norvegicus | 17 | ALA4428047 | organism-based format | Scientific Literature |