# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4375425 | A | Oral bioavailability in mouse at 5 mg/kg by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
2. | ALA4375430 | A | AUC in mouse at 5 mg/kg, ip by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
3. | ALA4375432 | A | AUC in mouse at 5 mg/kg, po by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
4. | ALA4375433 | A | Tmax in mouse at 5 mg/kg, po by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
5. | ALA4375434 | A | Tmax in mouse at 5 mg/kg, ip by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
6. | ALA4375435 | A | Cmax in mouse at 5 mg/kg, po by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
7. | ALA4375436 | A | Cmax in mouse at 5 mg/kg, ip by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
8. | ALA4375439 | B | Inhibition of mouse slc26a3 expressed in FRT cells co-expressing EYFP-H148Q/I152L/F46L assessed as reduction in protein-mediated chloride/iodide exchange preincubated for 10 mins followed by NaI-substituted PBS addition and measured by YFP-based fluorescence assay | Mus musculus | 45 | cell-based format | Scientific Literature | ||
9. | ALA4375444 | A | Time at which serum concentration stays above in vitro IC50 for inhibition of mouse slc26a3 expressed in FRT cells in mouse at 5 mg/kg, po or ip by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
10. | ALA5053125 | B | Inhibition of mouse Slc26a3 transfected in rat FRT cells preincubated with forskolin, 8-Br-cGMP and PMA and measured by fluorescence assay | Mus musculus | 51 | cell-based format | Patent Bioactivity Data | ||
11. | ALA5053126 | B | Inhibition of mouse Slc26a3 transfected in rat FRT cells at 10 uM preincubated with forskolin, 8-Br-cGMP and PMA and measured by fluorescence assay relative to control | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA5053127 | B | Inhibition of Slc26a3-mediated HCO3- influx/Cl efflux in rat FRT cells measured by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Patent Bioactivity Data | ||
13. | ALA5053128 | B | Inhibition of Slc26a3-mediated Cl-/SCN- exchange in rat FRT cells measured by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA5053129 | B | Inhibition of Slc26a3-mediated Cl-/ I- exchange in rat FRT cells assessed as half-life measured by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Patent Bioactivity Data | ||
15. | ALA5053130 | B | Inhibition of SLC26A3-mediated Cl-/ I- exchange in human HEK293 cells measured by fluorescence assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
16. | ALA5053131 | B | Inhibition of mouse Slc26a4-mediated Cl-/ I- exchange at 10 uM measured by cell-based fluorescence assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
17. | ALA5053132 | B | Inhibition of mouse Slc26a6-mediated Cl-/ I- exchange at 10 uM measured by cell-based fluorescence assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
18. | ALA5053133 | B | Inhibition of mouse Slc26a9-mediated Cl-/ I- exchange at 10 uM measured by cell-based fluorescence assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
19. | ALA5053134 | B | Inhibition of mouse CFTR at 10 uM measured by cell-based fluorescence assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
20. | ALA5053135 | B | Inhibition of mouse TMEM16A at 10 uM measured by cell-based fluorescence assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data |