# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4383079 | A | Volume of distribution at steady state in rat | Rattus norvegicus | 12 | ALA4382198 | assay format | Scientific Literature | |
2. | ALA4383096 | P | Dissociation constant, pKa of the compound | 13 | ALA4382198 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4478550 | B | Inhibition of mRNA splicing of SMN2 exon 7 in fibroblasts derived from human SMA type 1/2/3 patient assessed as increase in SMN protein level after 48 hrs by HTRF assay | Homo sapiens | 18 | ALA4477215 | assay format | Scientific Literature | |
4. | ALA4478551 | T | Mutagenicity in Salmonella typhimurium TA1535 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | ALA4477215 | subcellular format | Scientific Literature | |
5. | ALA4478552 | T | Mutagenicity in Salmonella typhimurium TA98 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | ALA4477215 | subcellular format | Scientific Literature | |
6. | ALA4478553 | T | Mutagenicity in Salmonella typhimurium TA97 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | ALA4477215 | subcellular format | Scientific Literature | |
7. | ALA4478554 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | ALA4477215 | subcellular format | Scientific Literature | |
8. | ALA4478555 | T | Mutagenicity in Salmonella typhimurium TA102 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | ALA4477215 | subcellular format | Scientific Literature | |
9. | ALA4478556 | B | Inhibition of mRNA splicing of SMN2 exon 7 in GM03813 fibroblasts derived from human SMA type 1 patient after 24 hrs by RT-qPCR analysis | Homo sapiens | 16 | ALA4477215 | assay format | Scientific Literature | |
10. | ALA4478558 | P | Octanol-aqueous phosphate buffer distribution coefficient, log D of the compound at pH 7.4 at 100 mM after 24 hrs by LC-MS based shake flask method | 8 | ALA4477215 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4478559 | B | Substrate activity at human P-gp assessed as efflux ratio by cell based assay | Homo sapiens | 8 | ALA4477215 | cell-based format | Scientific Literature | |
12. | ALA4478560 | B | Substrate activity at mouse P-gp assessed as efflux ratio by cell based assay | Mus musculus | 8 | ALA4477215 | cell-based format | Scientific Literature | |
13. | ALA4478561 | A | Clearance in rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA4477215 | organism-based format | Scientific Literature | |
14. | ALA4478562 | A | Volume of distribution at steady state in rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA4477215 | organism-based format | Scientific Literature | |
15. | ALA4478563 | A | Half life in rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA4477215 | organism-based format | Scientific Literature | |
16. | ALA4478564 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 3 | ALA4477215 | organism-based format | Scientific Literature | |
17. | ALA4478565 | A | Clearance in Cynomolgus monkey at 0.3 mg/kg, iv | Macaca fascicularis | 3 | ALA4477215 | organism-based format | Scientific Literature | |
18. | ALA4478566 | A | Volume of distribution at steady state in Cynomolgus monkey at 0.3 mg/kg, iv | Macaca fascicularis | 3 | ALA4477215 | organism-based format | Scientific Literature | |
19. | ALA4478567 | A | Half life in Cynomolgus monkey at 1 mg/kg, po | Macaca fascicularis | 3 | ALA4477215 | organism-based format | Scientific Literature | |
20. | ALA4478568 | A | Oral bioavailability in Cynomolgus monkey at 1 mg/kg | Macaca fascicularis | 3 | ALA4477215 | organism-based format | Scientific Literature |