# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4351501 | ADME | Displacement of [3H]-Ro15-4513 from human GABAA alpha4beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintillation counting method | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
2. | ALA4351502 | Binding | Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintillation counting method | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
3. | ALA4351503 | Binding | Displacement of [3H]Ro-15-1788 from human GABA alpha2/beta2/gamma2 receptor expressed in HEK cell membranes measured after 2 hrs by topcount method | Homo sapiens | 50 | ALA4350959 | cell-based format | Scientific Literature | |
4. | ALA4351504 | Binding | Displacement of [3H]-flumazenil from human GABAA alpha2beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintillation counting method | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
5. | ALA4351505 | ADME | Positive allosteric modulation of human GABAA alpha1/beta3/gamma2 expressed in HEK293 cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Homo sapiens | 50 | ALA4350959 | cell-based format | Scientific Literature | |
6. | ALA4351506 | Binding | Positive allosteric modulation of human GABAA alpha2/beta2/gamma2 expressed in HEK293 cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Homo sapiens | 50 | ALA4350959 | cell-based format | Scientific Literature | |
7. | ALA4351507 | ADME | Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintillation counting method | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
8. | ALA4351508 | Physicochemical | Lipophilicity, log D of the compound | 34 | ALA4350959 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4351509 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 46 | ALA4350959 | microsome format | Scientific Literature | |
10. | ALA4351510 | ADME | Efflux ratio of permeability across apical to basolateral side over basolateral to apical side in MDCK-MDR1 cells at 2 uM | Canis lupus familiaris | 46 | ALA4350959 | cell-based format | Scientific Literature | |
11. | ALA4351511 | Binding | Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintillation counting method | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
12. | ALA4351512 | ADME | Displacement of [3H]-Ro15-4513 from human GABAA alpha6beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintillation counting method | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
13. | ALA4351515 | Binding | Positive allosteric modulation of human GABAA alpha3/beta3/gamma2 expressed in HEK293 cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
14. | ALA4351517 | Binding | Positive allosteric modulation of human GABAA alpha5beta2gamma2 expressed in HEK293 cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Homo sapiens | 2 | ALA4350959 | cell-based format | Scientific Literature | |
15. | ALA4351519 | Binding | Displacement of [3H]-flumazenil from rat GABAA alpha1beta3gamma2 receptor expressed in CHO cell membranes measured after 2 hrs by liquid scintillation counting method | Rattus norvegicus | 2 | ALA4350959 | cell-based format | Scientific Literature | |
16. | ALA4351520 | Binding | Displacement of [3H]-flumazenil from rat GABAA alpha2beta3gamma2 receptor expressed in CHO cell membranes measured after 2 hrs by liquid scintillation counting method | Rattus norvegicus | 2 | ALA4350959 | cell-based format | Scientific Literature | |
17. | ALA4351521 | Binding | Positive allosteric modulation of rat GABAA alpha1beta3gamma2 receptor expressed in CHO cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Rattus norvegicus | 2 | ALA4350959 | cell-based format | Scientific Literature | |
18. | ALA4351522 | Binding | Positive allosteric modulation of rat GABAA alpha2beta3gamma2 receptor expressed in CHO cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Rattus norvegicus | 2 | ALA4350959 | cell-based format | Scientific Literature | |
19. | ALA4351523 | Physicochemical | Solubility of the compound at pH 6.5 | 2 | ALA4350959 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4351524 | ADME | Permeability in RRCK cells | Canis lupus familiaris | 2 | ALA4350959 | cell-based format | Scientific Literature |