| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4311836 | B | Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by chemifluorescence assay | Homo sapiens | 25 | ALA4308918 | single protein format | Scientific Literature | |
| 2. | ALA4311837 | B | Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by chemifluorescence assay | Homo sapiens | 25 | ALA4308918 | assay format | Scientific Literature | |
| 3. | ALA4311838 | B | Selectivity ratio of IC50 for full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 to IC50 for human PARP10 catalytic domain | Homo sapiens | 25 | ALA4308918 | assay format | Scientific Literature | |
| 4. | ALA4311840 | B | Inhibition of full length human PARP1 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | single protein format | Scientific Literature | |
| 5. | ALA4311841 | B | Inhibition of full length human PARP2 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | single protein format | Scientific Literature | |
| 6. | ALA4311842 | B | Inhibition of full length human PARP3 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | single protein format | Scientific Literature | |
| 7. | ALA4311843 | B | Inhibition of human PARP4 BRCT-catalytic domain (1 to 572 residues) assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | single protein format | Scientific Literature | |
| 8. | ALA4311844 | B | Inhibition of human PARP5B catalytic domain (1 to 572 residues) assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | single protein format | Scientific Literature | |
| 9. | ALA4311845 | B | Inhibition of GFP-tagged human PARP6 short isoform expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by chemiluminescent immunoprecipitation assay | Homo sapiens | 1 | ALA4308918 | cell-based format | Scientific Literature | |
| 10. | ALA4311846 | B | Inhibition of GFP-tagged human PARP6 long isoform expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by chemiluminescent immunoprecipitation assay | Homo sapiens | 1 | ALA4308918 | cell-based format | Scientific Literature | |
| 11. | ALA4311847 | B | Inhibition of human PARP7 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | single protein format | Scientific Literature | |
| 12. | ALA4311848 | B | Inhibition of GFP-tagged human PARP8 expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by chemiluminescent immunoprecipitation assay | Homo sapiens | 1 | ALA4308918 | cell-based format | Scientific Literature | |
| 13. | ALA4311849 | B | Inhibition of GFP-tagged human PARP12 expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by chemiluminescent immunoprecipitation assay | Homo sapiens | 1 | ALA4308918 | cell-based format | Scientific Literature | |
| 14. | ALA4311850 | B | Inhibition of human PARP14 catalytic-WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | assay format | Scientific Literature | |
| 15. | ALA4311851 | B | Inhibition of human PARP15 catalytic domain assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | single protein format | Scientific Literature | |
| 16. | ALA4311852 | B | Inhibition of human transmembrane domain deficient His-SUMO-tagged PARP16 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay | Homo sapiens | 1 | ALA4308918 | assay format | Scientific Literature | |
| 17. | ALA4311853 | B | Selectivity ratio of IC50 for full length human PARP1 to IC50 for human PARP10 catalytic domain | Homo sapiens | 1 | ALA4308918 | assay format | Scientific Literature | |
| 18. | ALA4311854 | B | Selectivity ratio of IC50 for full length human PARP2 to IC50 for human PARP10 catalytic domain | Homo sapiens | 1 | ALA4308918 | assay format | Scientific Literature | |
| 19. | ALA4311855 | B | Selectivity ratio of IC50 for full length human PARP3 to IC50 for human PARP10 catalytic domain | Homo sapiens | 1 | ALA4308918 | assay format | Scientific Literature | |
| 20. | ALA4311856 | B | Selectivity ratio of IC50 for human PARP4 BRCT-catalytic domain (1 to 572 residues) to IC50 for human PARP10 catalytic domain | Homo sapiens | 1 | ALA4308918 | assay format | Scientific Literature |
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