# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4361981 | A | Inhibition of electric eel AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine iodide as substrate measured for 125 secs by Ellman's method | Electrophorus electricus | 26 | single protein format | Scientific Literature | ||
2. | ALA4361982 | A | Inhibition of electric eel AChE assessed as dissociation constant for enzyme-substrate-inhibitor complex using acetylthiocholine iodide as substrate measured for 125 secs by Ellman's method | Electrophorus electricus | 23 | single protein format | Scientific Literature | ||
3. | ALA4361983 | B | Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured for 125 secs by Ellman's method | Equus caballus | 24 | single protein format | Scientific Literature | ||
4. | ALA4361984 | B | Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-substrate-inhibitor complex using butyrylthiocholine iodide as substrate measured for 125 secs by Ellman's method | Equus caballus | 23 | single protein format | Scientific Literature | ||
5. | ALA4361985 | A | Mixed-type inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 125 secs by Lineweaver-burk plot analysis | Electrophorus electricus | 9 | single protein format | Scientific Literature | ||
6. | ALA4361991 | A | Inhibition of human recombinant AChE expressed in HEK293 cells using acetylcholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 5 mins by Ellman's method | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
7. | ALA4361992 | B | Inhibition of human serum BuChe by Ellman's method | Homo sapiens | 12 | single protein format | Scientific Literature | ||
8. | ALA4361993 | U | Selectivity index, ratio of IC50 for human recombinant AChE expressed in HEK293 cells to IC50 for human serum BuChE | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
9. | ALA4361994 | B | Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation at 50 uM incubated for 48 hrs by thioflavin-T fluorescence method relative to control | Homo sapiens | 8 | single protein format | Scientific Literature | ||
10. | ALA4361996 | F | Neuroprotective activity against 6-OHDA-induced cytotoxicity in rat primary cerebellar granule neuron at 1 to 25 uM by MTT assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
11. | ALA4361997 | A | Cytotoxicity in rat Primary cerebellar granule neuron assessed as cell viability at 1 uM after 24 hrs by MTT assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
12. | ALA4362006 | A | Cytotoxicity against human HepG2 cells at 1 to 25 uM after 24 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4362011 | B | Potency index, ratio of tacrine IC50 to compound IC50 for human serum BuChe by Ellman's method | Homo sapiens | 2 | single protein format | Scientific Literature |