# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4410741 | Functional | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of C48/80-induced mast cell degranulation preincubated with compound for 30 mins and then treated with C48/80 for 1 hr by neutral red dye based method | Rattus norvegicus | 18 | ALA4406904 | cell-based format | Scientific Literature | |
2. | ALA4410742 | Functional | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of C48/80-induced histamine release preincubated with compound for 30 mins followed by C48/80 stimulation for 1 hr | Rattus norvegicus | 18 | ALA4406904 | cell-based format | Scientific Literature | |
3. | ALA4410743 | Functional | Antiallergic activity in IgE/Ag-stimulated rat RBL2H3 cells assessed as inhibition of HSA-induced beta-hexosaminidase release preincubated with compound for 30 mins and then stimulated with HSA for 15 mins followed by incubation with P-nitrophenyl-N-acetyl-beta-D-glucosaminide for 2 hrs | Rattus norvegicus | 18 | ALA4406904 | cell-based format | Scientific Literature | |
4. | ALA4410744 | Binding | Binding affinity to H1 receptor (unknown origin) at 0.10 umol/L | Homo sapiens | 5 | ALA4406904 | single protein format | Scientific Literature | |
5. | ALA4410745 | Functional | In vivo antiallergic activity in histamine-induced bronchospasm guinea pig model assessed as duration of convulsions at 20 mg/kg, po by Van Arman method | Cavia porcellus | 5 | ALA4406904 | organism-based format | Scientific Literature | |
6. | ALA4410747 | Functional | In vivo antiallergic activity in guinea pig assessed as protection against histamine-induced bronchospasm at 20 mg/kg, po by Van Arman method relative to control | Cavia porcellus | 5 | ALA4406904 | organism-based format | Scientific Literature | |
7. | ALA4410749 | Toxicity | Acute toxicity in ip dosed histamine-induced bronchospasm guinea pig model | Cavia porcellus | 6 | ALA4406904 | organism-based format | Scientific Literature | |
8. | ALA4410750 | Functional | Antiallergic activity in mouse assessed as inhibition of histamine-induced increase in capillary permeability by measuring Evans blue dye concentration at 20 mg/kg administered via gavage for 1 week followed by Evans blue dye injection immediately after subcutaneous histamine injection and measured after 15 mins by UV spectrophotometric analysis | Mus musculus | 6 | ALA4406904 | organism-based format | Scientific Literature | |
9. | ALA4410751 | Physicochemical | Lipid/water partition co-efficient, log P of the compound | 16 | ALA4406904 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4410752 | Physicochemical | Dissociation constant, pKa of the compound | 16 | ALA4406904 | small-molecule physicochemical format | Scientific Literature |