| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4478550 | B | Inhibition of mRNA splicing of SMN2 exon 7 in fibroblasts derived from human SMA type 1/2/3 patient assessed as increase in SMN protein level after 48 hrs by HTRF assay | Homo sapiens | 18 | assay format | Scientific Literature | ||
| 2. | ALA4478551 | T | Mutagenicity in Salmonella typhimurium TA1535 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | subcellular format | Scientific Literature | ||
| 3. | ALA4478552 | T | Mutagenicity in Salmonella typhimurium TA98 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | subcellular format | Scientific Literature | ||
| 4. | ALA4478553 | T | Mutagenicity in Salmonella typhimurium TA97 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | subcellular format | Scientific Literature | ||
| 5. | ALA4478554 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | subcellular format | Scientific Literature | ||
| 6. | ALA4478555 | T | Mutagenicity in Salmonella typhimurium TA102 assessed as increase in revertant colonies after 2 days in presence of rat liver S9 fraction by Ames test relative to control | Salmonella enterica subsp. enterica serovar Typhimurium | 16 | subcellular format | Scientific Literature | ||
| 7. | ALA4478556 | B | Inhibition of mRNA splicing of SMN2 exon 7 in GM03813 fibroblasts derived from human SMA type 1 patient after 24 hrs by RT-qPCR analysis | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 8. | ALA4478557 | F | Phototoxicity in mouse 3T3 cells in presence of UVA irradiation | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4478606 | A | Stability of the compound in human plasma | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 10. | ALA4478607 | P | Stability of the compound in pH 1 to 12 aqueous buffer | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4478610 | B | Inhibition of mRNA splicing of human SMN2 exon 7 transfected in HEK293H cells assessed as compound concentration required to increase full-length SMN2 mRNA level by 1.5 times after 24 hrs by RT-qPCR analysis relative to GAPDH | Homo sapiens | 57 | cell-based format | Scientific Literature | ||
| 12. | ALA4478614 | B | Inhibition of mRNA splicing of SMN2 exon 7 in GM03813 fibroblasts derived from SMA patient assessed as compound concentration required to increase SMN protein level by 1.5 times after 24 hrs by HTRF assay | Homo sapiens | 59 | assay format | Scientific Literature | ||
| 13. | ALA4478616 | A | Apparent permeability in human Caco2 cells | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 14. | ALA4478617 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in human Caco2 cells | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 15. | ALA4478618 | A | Protein binding in human plasma | Homo sapiens | 7 | cell-free format | Scientific Literature | ||
| 16. | ALA4478619 | A | AUC (0 to 6 hrs) in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 11 | organism-based format | Scientific Literature | ||
| 17. | ALA4478620 | A | Ratio of drug level in brain to plasma of Sprague-Dawley rat at 10 mg/kg, po measured at 6 hrs | Rattus norvegicus | 11 | organism-based format | Scientific Literature | ||
| 18. | ALA4478621 | A | AUC (0 to 24 hrs) in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse at 10 mg/kg, ip | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4478622 | A | Ratio of drug level in brain to plasma of FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse at 10 mg/kg, ip | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4478628 | F | In vivo inhibition of mRNA splicing of human SMN2 exon 7 in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse assessed as median survival time at 1 mg/kg/day, ip administered on postnatal day 3 to day 23 (Rvb = 14 days) | Mus musculus | 2 | organism-based format | Scientific Literature |
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