# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4332420 | F | Antiviral activity against HCV genotype 2a JFH/JC1 infected in human Huh7.5 cells assessed as inhibition of viral RNA replication after 72 hrs by qRT-PCR analysis | Hepacivirus hominis | 4 | ALA4330116 | organism-based format | Scientific Literature | |
2. | ALA4332421 | A | Cytotoxicity against human Huh7.5 cells after 72 hrs by MTT assay | Homo sapiens | 4 | ALA4330116 | cell-based format | Scientific Literature | |
3. | ALA4332422 | T | Selectivity index, ratio of CC50 for human Huh7.5 cells to EC50 for antiviral activity against HCV genotype 2a JFH/JC1 infected in human Huh7.5 cells | 4 | ALA4330116 | cell-based format | Scientific Literature | ||
4. | ALA4332423 | F | Antiviral activity against HCV pseudoparticles infected in human Huh7.5 cells infected with HCV pseudoparticles expressed in 293T cells with plasmid encoding HCV E1, E2, envelope and Vpr deficient HIV vector carrying luciferase reporter gene inserted into Nef position assessed as inhibition of pseudoparticle entry after 72 hrs by luciferase reporter gene assay | Hepacivirus hominis | 2 | ALA4330116 | organism-based format | Scientific Literature | |
5. | ALA4332424 | F | Antiviral activity against VSV pseudoparticles infected in human Huh7.5 cells infected with VSV pseudoparticles expressed in 293T cells with plasmid encoding vesicular stomatitis G protein, envelope and Vpr deficient HIV vector carrying luciferase reporter gene inserted into Nef position assessed as inhibition of pseudoparticle entry at 6.25 to 100 uM after 72 hrs by luciferase reporter gene assay | Vesicular stomatitis virus | 2 | ALA4330116 | organism-based format | Scientific Literature | |
6. | ALA4332425 | B | Binding affinity to CD81 (unknown origin) by surface plasmon resonance assay | Homo sapiens | 2 | ALA4330116 | single protein format | Scientific Literature | |
7. | ALA4332426 | B | Binding affinity to CD81 (unknown origin) assessed as association rate constant by surface plasmon resonance assay | Homo sapiens | 2 | ALA4330116 | single protein format | Scientific Literature | |
8. | ALA4332427 | B | Binding affinity to CD81 (unknown origin) assessed as dissociation rate constant by surface plasmon resonance assay | Homo sapiens | 2 | ALA4330116 | single protein format | Scientific Literature | |
9. | ALA4332428 | B | Binding affinity to CD81 (unknown origin) assessed as disruption of interaction between CD81 the HCV envelope protein E2 at 5 uM by surface plasmon resonance assay relative to untreated control | Homo sapiens | 1 | ALA4330116 | single protein format | Scientific Literature | |
10. | ALA4332429 | B | Binding affinity to CD81 (unknown origin) assessed as disruption of interaction between CD81 the HCV envelope protein E2 by measuring Kd for CD81/E2 interaction at 5 uM by surface plasmon resonance assay (Rvb = 1.3 nM) | Homo sapiens | 1 | ALA4330116 | single protein format | Scientific Literature |