# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4433109 | Binding | Inhibition of Keap1 Kelch domain/FITC-9mer Nrf2 (unknown origin) interaction after 30 mins by fluorescence polarization assay | Homo sapiens | 9 | ALA4431393 | protein format | Scientific Literature | |
2. | ALA4433110 | Physicochemical | Intrinsic solubility of the compound at pH 7.4 by potentiometric acid-base titration method | 9 | ALA4431393 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4433111 | Physicochemical | Dissociation constant, pKa of the compound by Avdeef-Bucher potentiometric titration method | 9 | ALA4431393 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4433112 | Physicochemical | Partition coefficient, logD of the compound at pH 7.4 by Avdeef-Bucher potentiometric titration method | 9 | ALA4431393 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4433124 | Binding | Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE activity at 1 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4431393 | cell-based format | Scientific Literature | |
6. | ALA4433125 | Binding | Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE activity at 0.1 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4431393 | cell-based format | Scientific Literature | |
7. | ALA4433126 | Binding | Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE activity at 5 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4431393 | cell-based format | Scientific Literature | |
8. | ALA4433128 | Binding | Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE activity at 0.01 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4431393 | cell-based format | Scientific Literature |