| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4414022 | B | Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 2. | ALA4414023 | B | Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincubated for 30 to 60 mins followed by substrate addition and measured after 30 mins bpV-based fluorescence assay | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 3. | ALA4414024 | F | Antiproliferative activity against human KYSE520 cells added 24 hrs after cell plating and measured on day 5 by Celltiter-Glo assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA4414026 | B | Inhibition of human ERG | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 5. | ALA4414027 | A | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4414028 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 7. | ALA4414029 | A | Half life in rat liver microsomes | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 8. | ALA4414030 | A | Dose normalized AUC in rat at 1 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 9. | ALA4414031 | A | Oral bioavailability in rat at 1 mg/kg | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA4414032 | F | In vivo inhibition of SHP2 in human KYSE520 cells xenografted in NU/NU mouse assessed as reduction in phosphorylated ERK levels at 100 mg/kg, po administered as single dose after 3 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4414033 | F | In vivo inhibition of SHP2 in human KYSE520 cells xenografted in NU/NU mouse assessed as reduction in DUSP6 mRNA levels at 100 mg/kg, po administered as single dose after 3 hrs by qPCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4414034 | A | Protein binding in mouse plasma | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 13. | ALA4414041 | F | Antiproliferative activity against human Detroit 562 cells after 24 hrs by Celltiter-Glo assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4414047 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4414048 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4414049 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature |
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