# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4332101 | F | Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay | Homo sapiens | 3 | ALA4330101 | single protein format | Scientific Literature | |
2. | ALA4332102 | B | Agonist activity at human PPARgamma | Homo sapiens | 27 | ALA4330101 | single protein format | Scientific Literature | |
3. | ALA4332103 | B | Agonist activity at human PPARgamma at 1 uM relative to pioglitazone | Homo sapiens | 27 | ALA4330101 | single protein format | Scientific Literature | |
4. | ALA4332104 | B | Agonist activity at PPARgamma in mouse 3T3L1 cells assessed as increase in AP1 mRNA expression at 10 uM after 24 hrs by SYBR green dye based RT-PCR analysis | Mus musculus | 4 | ALA4330101 | cell-based format | Scientific Literature | |
5. | ALA4332105 | B | Agonist activity at PPARgamma in mouse 3T3L1 cells assessed as increase in CD36 mRNA expression at 10 uM after 24 hrs by SYBR green dye based RT-PCR analysis | Mus musculus | 4 | ALA4330101 | cell-based format | Scientific Literature | |
6. | ALA4332106 | B | Agonist activity at PPARgamma in mouse 3T3L1 cells assessed as increase in Glut4 mRNA expression at 10 uM after 24 hrs by SYBR green dye based RT-PCR analysis | Mus musculus | 4 | ALA4330101 | cell-based format | Scientific Literature | |
7. | ALA4332107 | B | Agonist activity at PPARgamma in mouse 3T3L1 cells assessed as increase in adiponectin mRNA expression at 10 uM after 24 hrs by SYBR green dye based RT-PCR analysis | Mus musculus | 4 | ALA4330101 | cell-based format | Scientific Literature | |
8. | ALA4332108 | B | Binding affinity to PPARgamma (unknown origin) by TR-FRET competitive binding assay | Homo sapiens | 1 | ALA4330101 | single protein format | Scientific Literature | |
9. | ALA4332109 | B | Binding affinity to PPARalpha (unknown origin) by TR-FRET competitive binding assay | Homo sapiens | 1 | ALA4330101 | single protein format | Scientific Literature | |
10. | ALA4332110 | B | Binding affinity to PPARdelta (unknown origin) by TR-FRET competitive binding assay | Homo sapiens | 1 | ALA4330101 | single protein format | Scientific Literature | |
11. | ALA4332111 | B | Selectivity ratio of IC50 for PPARalpha (unknown origin) to IC50 for PPARgamma (unknown origin) | Homo sapiens | 1 | ALA4330101 | assay format | Scientific Literature | |
12. | ALA4332112 | B | Selectivity ratio of IC50 for PPARdelta (unknown origin) to IC50 for PPARgamma (unknown origin) | Homo sapiens | 1 | ALA4330101 | protein format | Scientific Literature | |
13. | ALA4332113 | A | Stability in mouse liver microsomes assessed as parent compound remaining after 30 mins | Mus musculus | 27 | ALA4330101 | microsome format | Scientific Literature | |
14. | ALA4332114 | A | Stability in rat liver microsomes assessed as parent compound remaining after 30 mins | Rattus norvegicus | 4 | ALA4330101 | microsome format | Scientific Literature | |
15. | ALA4332115 | A | Stability in dog liver microsomes assessed as parent compound remaining after 30 mins | Canis lupus familiaris | 4 | ALA4330101 | microsome format | Scientific Literature | |
16. | ALA4332116 | A | Stability in human liver microsomes assessed as parent compound remaining after 30 mins | Homo sapiens | 27 | ALA4330101 | microsome format | Scientific Literature | |
17. | ALA4332117 | A | Inhibition of CYP1A2 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4330101 | single protein format | Scientific Literature | |
18. | ALA4332118 | A | Inhibition of CYP2C9 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4330101 | single protein format | Scientific Literature | |
19. | ALA4332119 | A | Inhibition of CYP2C19 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4330101 | single protein format | Scientific Literature | |
20. | ALA4332120 | A | Inhibition of CYP2D6 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4330101 | single protein format | Scientific Literature |