| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4402444 | Binding | Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mins by HTRF assay | Homo sapiens | 22 | ALA4400582 | single protein format | Scientific Literature | |
| 2. | ALA4402445 | Binding | Inhibition of TYK2 JH2 domain in IFNalpha/IL23-stimulated human Kit225 cells by luciferase reporter assay | Homo sapiens | 22 | ALA4400582 | assay format | Scientific Literature | |
| 3. | ALA4402446 | Binding | Inhibition of TYK2 JH2 domain in human whole blood assessed as decrease in IFNalpha/IL2-induced STAT phosphorylation preincubated for 1 hr followed by IFNalpha/IL2 stimulation and measured after 15 mins by fluorescence assay | Homo sapiens | 22 | ALA4400582 | tissue-based format | Scientific Literature | |
| 4. | ALA4402447 | ADME | Stability in human liver microsomes assessed as parent compound remaining | Homo sapiens | 4 | ALA4400582 | microsome format | Scientific Literature | |
| 5. | ALA4402448 | ADME | Stability in rat liver microsomes assessed as parent compound remaining | Rattus norvegicus | 4 | ALA4400582 | microsome format | Scientific Literature | |
| 6. | ALA4402449 | ADME | Stability in mouse liver microsomes assessed as parent compound remaining | Mus musculus | 4 | ALA4400582 | microsome format | Scientific Literature |
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