# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345696 | Binding | Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assay | Homo sapiens | 44 | ALA4342505 | assay format | Scientific Literature | |
2. | ALA4345697 | Physicochemical | Kinetic solubility in HEPES buffer containing 5% DMSO at pH 8 incubated for 20 hrs by NMR analysis | 48 | ALA4342505 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4345698 | Binding | Inhibition of recombinant human Nanoluc-tagged BCL6/Halo-tagged SMRT transfected in human HEK293T cells assessed as reduction in BCL6/SMRT interaction incubated for 6 hrs by NANOBRET assay | Homo sapiens | 18 | ALA4342505 | cell-based format | Scientific Literature | |
4. | ALA4345699 | Physicochemical | Kinetic solubility in PBS buffer containing 1% DMSO at pH 7.4 incubated for 2 hrs by HPLC analysis | 7 | ALA4342505 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4345700 | Binding | Induction of BCL6 degradation in human SUDHL-4 cells incubated for 2 hrs by immunofluorescence analysis | Homo sapiens | 28 | ALA4342505 | cell-based format | Scientific Literature | |
6. | ALA4345701 | Binding | Induction of BCL6 degradation in human SUDHL-4 cells at 10 uM incubated for 2 hrs by immunofluorescence analysis relative to control | Homo sapiens | 24 | ALA4342505 | cell-based format | Scientific Literature | |
7. | ALA4345702 | ADME | Permeability of compound by PAMPA assay | 2 | ALA4342505 | assay format | Scientific Literature | ||
8. | ALA4345703 | Binding | Induction of BCL6 degradation in human SUDHL-4 cells incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4342505 | cell-based format | Scientific Literature | |
9. | ALA4345704 | Binding | Induction of BCL6 degradation in human OCI-LY1 cells incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4342505 | cell-based format | Scientific Literature | |
10. | ALA4345705 | ADME | Metabolic stability in CD-1 mouse liver microsomes assessed as intrinsic clearance at 1 uM measured upt0 30 mins by LC-MS/MS analysis | Mus musculus | 14 | ALA4342505 | microsome format | Scientific Literature | |
11. | ALA4345706 | Binding | Induction of BCL6 degradation in human OCI-LY1 cells incubated for 2 hrs by MSD electrochemiluminescent immunoassay | Homo sapiens | 5 | ALA4342505 | cell-based format | Scientific Literature | |
12. | ALA4345707 | Binding | Induction of BCL6 degradation in human KARPAS422 cells incubated for 2 hrs by MSD electrochemiluminescent immunoassay | Homo sapiens | 5 | ALA4342505 | cell-based format | Scientific Literature | |
13. | ALA4345708 | Functional | Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay | Homo sapiens | 5 | ALA4342505 | cell-based format | Scientific Literature | |
14. | ALA4345709 | Functional | Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay | Homo sapiens | 5 | ALA4342505 | cell-based format | Scientific Literature | |
15. | ALA4345710 | Functional | Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay | Homo sapiens | 5 | ALA4342505 | assay format | Scientific Literature | |
16. | ALA4345731 | Physicochemical | Lipophilicity, log D of compound at pH 7.4 | 14 | ALA4342505 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA5223601 | Binding | Inhibition of human BCL6 BTP domain measured by TR-FRET assay | Homo sapiens | 16 | ALA5223079 | single protein format | Scientific Literature | |
18. | ALA5223614 | Binding | Induction of degradation of human BCL6 BTP domain by immunofluorescence (IF) staining assay | Homo sapiens | 2 | ALA5223079 | single protein format | Scientific Literature |