# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345863 | Binding | Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and measured after 30 mins by TR-FRET assay | Homo sapiens | 25 | ALA4342511 | single protein format | Scientific Literature | |
2. | ALA4345864 | Binding | Selectivity index, ratio of IC50 for GST-tagged human RET expressed in baculovirus to IC50 for recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) | Homo sapiens | 24 | ALA4342511 | assay format | Scientific Literature | |
3. | ALA4345865 | Binding | Selectivity index, ratio of IC50 for N-terminal His6-tagged recombinant human KDR (790 to end residue) expressed in baculovirus in Sf21 insect cells to IC50 for recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) | Homo sapiens | 25 | ALA4342511 | cell-based format | Scientific Literature | |
4. | ALA4345866 | Binding | Inhibition of RET V804M mutant (unknown origin)expressed in human BaF3 cells assessed as reduction in cell viability incubated for 48 hrs by celltiter glo luminescence cell viability assay | Homo sapiens | 14 | ALA4342511 | cell-based format | Scientific Literature | |
5. | ALA4345867 | Binding | Selectivity index, ratio of IC50 for RET (unknown origin) expressed in BaF3 cells to IC50 for RET V804M mutant (unknown origin) expressed in human BaF3 cells | Homo sapiens | 14 | ALA4342511 | cell-based format | Scientific Literature | |
6. | ALA4345868 | Binding | Selectivity index, ratio of IC50 for KDR (unknown origin) expressed in BaF3 cells to IC50 for RET V804M mutant (unknown origin) expressed in human BaF3 cells | Homo sapiens | 14 | ALA4342511 | cell-based format | Scientific Literature | |
7. | ALA4345869 | Physicochemical | Kinetic solubility of compound | 2 | ALA4342511 | small-molecule physicochemical format | Scientific Literature |