# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4329902 | Binding | Inhibition of HCV genotype 2a JFH1 NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene assay | Hepatitis C virus JFH-1 | 14 | ALA4325928 | cell-based format | Scientific Literature | |
2. | ALA4329905 | ADME | Half life in human liver microsomes | Homo sapiens | 4 | ALA4325928 | microsome format | Scientific Literature | |
3. | ALA4329906 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 4 | ALA4325928 | microsome format | Scientific Literature | |
4. | ALA4329907 | ADME | Permeability of the compound at pH 7.4 by PAMPA | 10 | ALA4325928 | assay format | Scientific Literature | ||
5. | ALA4329908 | ADME | Efflux ratio of permeability from basolateral side to apical side over apical side to basolateral side in human Caco2 cells expressing p-gp at 3 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 11 | ALA4325928 | cell-based format | Scientific Literature | |
6. | ALA4329909 | ADME | Permeability across apical side to basolateral side in human Caco2 cells expressing p-gp at 3 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 11 | ALA4325928 | cell-based format | Scientific Literature | |
7. | ALA4329910 | ADME | Permeability across basolateral side to apical side in human Caco2 cells expressing p-gp at 3 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 11 | ALA4325928 | cell-based format | Scientific Literature | |
8. | ALA4329917 | ADME | Drug level in cannulated Sprague-Dawley rat plasma at 6 mg/kg, po administered via gastric gavage measured after 5 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4325928 | organism-based format | Scientific Literature | |
9. | ALA4329918 | ADME | Drug level in cannulated Sprague-Dawley rat liver at 6 mg/kg, po administered via gastric gavage measured after 5 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4325928 | organism-based format | Scientific Literature |