# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4312978 | Binding | Induction of CRBN-mediated CDK6 degradation in human U251 cells after 24 hrs by immunoblot analysis | Homo sapiens | 20 | ALA4311951 | cell-based format | Scientific Literature | |
2. | ALA4312979 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells after 24 hrs by immunoblot analysis | Homo sapiens | 17 | ALA4311951 | cell-based format | Scientific Literature | |
3. | ALA4312986 | Binding | Induction of CRBN-mediated CDK6 degradation in human U251 cells at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 8 | ALA4311951 | cell-based format | Scientific Literature | |
4. | ALA4312987 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 8 | ALA4311951 | cell-based format | Scientific Literature | |
5. | ALA4313061 | Binding | Induction of CRBN-mediated CDK6 degradation in human DAOY cells at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 8 | ALA4311951 | cell-based format | Scientific Literature | |
6. | ALA4628824 | Binding | Inhibition of human CDK4/cyclin-D1 using RB protein as substrate by [gamma-33P]-ATP assay | Homo sapiens | 10 | ALA4627338 | protein complex format | Scientific Literature | |
7. | ALA4628825 | Binding | Inhibition of human CDK6/cyclin-D3 using RB protein as substrate by [gamma-33P]-ATP assay | Homo sapiens | 10 | ALA4627338 | protein complex format | Scientific Literature | |
8. | ALA4628828 | Binding | Protac activity at CRBN/CDK4 in human Jurkat cells assessed as induction of CDK4 degradation measured after 24 hrs by capillary electrophoresis | Homo sapiens | 4 | ALA4627338 | cell-based format | Scientific Literature | |
9. | ALA4628829 | Binding | Protac activity at CRBN/CDK6 in human Jurkat cells assessed as induction of CDK6 degradation measured after 24 hrs by capillary electrophoresis | Homo sapiens | 4 | ALA4627338 | cell-based format | Scientific Literature | |
10. | ALA4840233 | Binding | Protac activity at VHL/CDK4 in human MM1.S cells assessed as induction of CDK4 degradation at 0.1 to 1 uM measured after 16 hrs by Western blotting analysis | Homo sapiens | 6 | ALA4837268 | cell-based format | Scientific Literature | |
11. | ALA4840234 | Binding | Protac activity at VHL/CDK6 in human MM1.S cells assessed as induction of CDK6 degradation at 0.1 to 1 uM measured after 16 hrs by Western blotting analysis | Homo sapiens | 6 | ALA4837268 | cell-based format | Scientific Literature | |
12. | ALA4840235 | Binding | Protac activity at CRBN/IKZF3 in human MM1.S cells assessed as induction of IKZF3 degradation at 0.1 to 1 uM measured after 16 hrs by Western blotting analysis | Homo sapiens | 4 | ALA4837268 | cell-based format | Scientific Literature | |
13. | ALA4840236 | Functional | Cytotoxicity against human MM1.S cells assessed as effect on cell viability at 0.1 to 10 uM incubated for 72 hrs by luminescence based analysis | Homo sapiens | 2 | ALA4837268 | cell-based format | Scientific Literature | |
14. | ALA4840237 | Physicochemical | Aqueous stability of the compound at pH 7.4 assessed as compound decomposition measured after 96 hrs by HPLC analysis | 2 | ALA4837268 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4840238 | Binding | Protac activity at VHL/CDK6 in human MM1.S cells assessed as protein levels at 1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 5 | ALA4837268 | cell-based format | Scientific Literature | |
16. | ALA4840239 | Binding | Protac activity at VHL/CDK6 in human MM1.S cells assessed as protein levels at 1 uM measured after 72 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA4837268 | cell-based format | Scientific Literature | |
17. | ALA4840240 | Binding | Protac activity at VHL/CDK4 in human MM1.S cells assessed as protein levels at 1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 5 | ALA4837268 | cell-based format | Scientific Literature | |
18. | ALA4840241 | Binding | Protac activity at VHL/CDK4 in human MM1.S cells assessed as protein levels at 1 uM measured after 72 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA4837268 | cell-based format | Scientific Literature | |
19. | ALA4840242 | Binding | Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as protein levels at 1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 5 | ALA4837268 | cell-based format | Scientific Literature | |
20. | ALA4840243 | Binding | Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as protein levels at 1 uM measured after 72 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA4837268 | cell-based format | Scientific Literature |