| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4312978 | B | Induction of CRBN-mediated CDK6 degradation in human U251 cells after 24 hrs by immunoblot analysis | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 2. | ALA4312979 | B | Induction of CRBN-mediated CDK4 degradation in human U251 cells after 24 hrs by immunoblot analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 3. | ALA4312986 | B | Induction of CRBN-mediated CDK6 degradation in human U251 cells at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 4. | ALA4312987 | B | Induction of CRBN-mediated CDK4 degradation in human U251 cells at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA4313061 | B | Induction of CRBN-mediated CDK6 degradation in human DAOY cells at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 6. | ALA4628824 | B | Inhibition of human CDK4/cyclin-D1 using RB protein as substrate by [gamma-33P]-ATP assay | Homo sapiens | 10 | protein complex format | Scientific Literature | ||
| 7. | ALA4628825 | B | Inhibition of human CDK6/cyclin-D3 using RB protein as substrate by [gamma-33P]-ATP assay | Homo sapiens | 10 | protein complex format | Scientific Literature | ||
| 8. | ALA4628828 | B | Protac activity at CRBN/CDK4 in human Jurkat cells assessed as induction of CDK4 degradation measured after 24 hrs by capillary electrophoresis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4628829 | B | Protac activity at CRBN/CDK6 in human Jurkat cells assessed as induction of CDK6 degradation measured after 24 hrs by capillary electrophoresis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4840233 | B | Protac activity at VHL/CDK4 in human MM1.S cells assessed as induction of CDK4 degradation at 0.1 to 1 uM measured after 16 hrs by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 11. | ALA4840234 | B | Protac activity at VHL/CDK6 in human MM1.S cells assessed as induction of CDK6 degradation at 0.1 to 1 uM measured after 16 hrs by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA4840235 | B | Protac activity at CRBN/IKZF3 in human MM1.S cells assessed as induction of IKZF3 degradation at 0.1 to 1 uM measured after 16 hrs by Western blotting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4840236 | F | Cytotoxicity against human MM1.S cells assessed as effect on cell viability at 0.1 to 10 uM incubated for 72 hrs by luminescence based analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4840237 | P | Aqueous stability of the compound at pH 7.4 assessed as compound decomposition measured after 96 hrs by HPLC analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA4840238 | B | Protac activity at VHL/CDK6 in human MM1.S cells assessed as protein levels at 1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA4840239 | B | Protac activity at VHL/CDK6 in human MM1.S cells assessed as protein levels at 1 uM measured after 72 hrs by Western blot analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA4840240 | B | Protac activity at VHL/CDK4 in human MM1.S cells assessed as protein levels at 1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 18. | ALA4840241 | B | Protac activity at VHL/CDK4 in human MM1.S cells assessed as protein levels at 1 uM measured after 72 hrs by Western blot analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4840242 | B | Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as protein levels at 1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 20. | ALA4840243 | B | Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as protein levels at 1 uM measured after 72 hrs by Western blot analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!