# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4307089 | Binding | Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysis | Homo sapiens | 24 | ALA4304781 | cell-based format | Scientific Literature | |
2. | ALA4307090 | ADME | Inhibition of human recombinant CYP11B1 using deoxycortisol as substrate incubated for 60 mins by cell-based HPLC analysis | Homo sapiens | 24 | ALA4304781 | cell-based format | Scientific Literature | |
3. | ALA4307091 | Binding | Selectivity index, ratio of IC50 for human recombinant CYP11B1 to IC50 for human recombinant CYP11B2 | Homo sapiens | 23 | ALA4304781 | assay format | Scientific Literature | |
4. | ALA4307092 | ADME | Stability in cynomolgus monkey liver microsomes assessed as parent compound remaining at 1 uM measured after 65 mins by LC/MS-MS analysis | Macaca fascicularis | 13 | ALA4304781 | microsome format | Scientific Literature | |
5. | ALA4307093 | ADME | Cmax in cynomolgus monkey at 1 mg/kg, po measured after 24 or 72 hrs | Macaca fascicularis | 6 | ALA4304781 | organism-based format | Scientific Literature | |
6. | ALA4307094 | ADME | Tmax in cynomolgus monkey at 1 mg/kg, po measured after 24 or 72 hrs | Macaca fascicularis | 6 | ALA4304781 | organism-based format | Scientific Literature | |
7. | ALA4307095 | ADME | AUC (0 to 24 hrs) in cynomolgus monkey at 1 mg/kg, po measured after 24 or 72 hrs | Macaca fascicularis | 6 | ALA4304781 | organism-based format | Scientific Literature | |
8. | ALA4307096 | ADME | Half life in cynomolgus monkey at 1 mg/kg, po measured after 24 or 72 hrs | Macaca fascicularis | 6 | ALA4304781 | organism-based format | Scientific Literature |