#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4352155	Binding	Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2''3'']indolizino[8'',7'':5',6']pyrano[3',2':3,4]pyrido-[1,2-a]indol-5-ium-2-sulfonate binding to human GST/His-tagged RIP1 (1 to 375) expressed in baculovirus expression system preincubated for 10 mins followed by fluorescently labeled ATP-competitive ligand addition and measured after 20 mins by fluorescence polarization assay	Homo sapiens	72	ALA4350963	assay format	Scientific Literature
2.	ALA4352156	Binding	Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation measured after 4 hrs in presence of ATP by ADP-Glo luminescence assay	Homo sapiens	60	ALA4350963	assay format	Scientific Literature
3.	ALA4352157	Binding	Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necroptosis measured after 24 hrs by cell titer-glo luminescent cell viability assay	Homo sapiens	72	ALA4350963	cell-based format	Scientific Literature
4.	ALA4352174	Physicochemical	Chromatographic hydrophobicity index, log D of the compound at pH 7.4 by reverse-phase HPLC analysis		68	ALA4350963	small-molecule physicochemical format	Scientific Literature
5.	ALA4352175	ADME	Half life in rat microsomes	Rattus norvegicus	31	ALA4350963	microsome format	Scientific Literature
6.	ALA4352177	ADME	Half life in human microsomes	Homo sapiens	31	ALA4350963	microsome format	Scientific Literature
7.	ALA4352206	ADME	Clearance in rat at 1 mg/kg, iv	Rattus norvegicus	9	ALA4350963	organism-based format	Scientific Literature
8.	ALA4352207	ADME	Volume of distribution at steady state in rat at 1 mg/kg, iv	Rattus norvegicus	9	ALA4350963	organism-based format	Scientific Literature
9.	ALA4352208	ADME	Half life in rat at 1 mg/kg, iv	Rattus norvegicus	9	ALA4350963	organism-based format	Scientific Literature
10.	ALA4352209	ADME	AUC (0 to infinity) in rat at 1 mg/kg, iv	Rattus norvegicus	9	ALA4350963	organism-based format	Scientific Literature