| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4381084 | F | Cytotoxicity against human PANC1 cells assessed as reduction in metabolic activity at 20 nM after 24 to 72 hrs in dark followed by photoirradiation in presence of NADH by resazurin assay | Homo sapiens | 4 | ALA4376882 | cell-based format | Scientific Literature | |
| 2. | ALA4381085 | A | Drug uptake in mouse NIH/3T3 cells at 5 uM and 4 degree C after 16 hrs by FACS analysis relative to 37 degree C | Mus musculus | 2 | ALA4376882 | cell-based format | Scientific Literature | |
| 3. | ALA4381086 | B | Binding affinity to NRAS RNA g-quadruplex (unknown origin) by fluorescence spectroscopy | Not specified | 3 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 4. | ALA4381087 | B | Binding affinity to human KRAS utr-1 RNA g-quadruplex by fluorescence spectroscopy | Homo sapiens | 3 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 5. | ALA4381088 | B | Binding affinity to human KRAS utr-c RNA g-quadruplex by fluorescence spectroscopy | Homo sapiens | 3 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 6. | ALA4381089 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex by fluorescence spectroscopy | Homo sapiens | 3 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 7. | ALA4381090 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex assessed as induction of hypochromicity at 1.6 uM by UV-vis spectrophotometry relative to control | Homo sapiens | 1 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 8. | ALA4381091 | P | Aggregation property of compound at > 40 degree C | 2 | ALA4376882 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4381092 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex assessed as emission spectra at absorbance 650 to 715 nm 1 uM by fluorescence titration method | Homo sapiens | 1 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 10. | ALA4381093 | B | Binding affinity to NRAS RNA g-quadruplex (unknown origin) at 40 degree C by SPR analysis | Not specified | 4 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 11. | ALA4381094 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex at 40 degree C by SPR analysis | Homo sapiens | 4 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 12. | ALA4381095 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex assessed as compound-RNA complex stoichiometry ratio of 6:1 by Job's plot analysis | Homo sapiens | 1 | ALA4376882 | nucleic acid format | Scientific Literature | |
| 13. | ALA4381100 | A | Drug uptake in human PANC1 cells at 5 uM after 16 hrs by FACS analysis | Homo sapiens | 4 | ALA4376882 | cell-based format | Scientific Literature | |
| 14. | ALA4381101 | A | Drug uptake in human PANC1 cells at 5 uM after 2 hrs by FACS analysis | Homo sapiens | 4 | ALA4376882 | cell-based format | Scientific Literature | |
| 15. | ALA4381102 | A | Drug localization in cytoplasm of human PANC1 cells at 5 uM after 6 hrs by Hoechst staining based confocal microscopy | Homo sapiens | 2 | ALA4376882 | subcellular format | Scientific Literature | |
| 16. | ALA4381103 | A | Drug uptake in human PANC1 cells in presence of dynamin-inhibitor dynasore | Homo sapiens | 3 | ALA4376882 | cell-based format | Scientific Literature | |
| 17. | ALA4381104 | A | Drug uptake in human PANC1 cells at 5 uM and 4 degree C after 16 hrs by FACS analysis relative to 37 degree C | Homo sapiens | 2 | ALA4376882 | cell-based format | Scientific Literature | |
| 18. | ALA4381105 | A | Drug uptake in human HEK293 cells at 5 uM and 4 degree C after 16 hrs by FACS analysis relative to 37 degree C | Homo sapiens | 2 | ALA4376882 | cell-based format | Scientific Literature | |
| 19. | ALA4381112 | F | Induction of ROS generation in human PANC1 cells assessed as cleavage of CM-H2DCFDA to CM-H2DCF by intracellular esterase by measuring green fluorescence emission incubated for 16 hrs followed by 7.2J/cm2 photoirradiation and subsequent compound washout measured after 40 mins by CM-H2DCFDA staining-based FACSCalibur flow cytometry | Homo sapiens | 1 | ALA4376882 | cell-based format | Scientific Literature | |
| 20. | ALA4381113 | F | Induction of ROS generation in human PANC1 cells cleavage of CM-H2DCFDA to CM-H2DCF by intracellular esterase by measuring green fluorescence emission incubated for 16 hrs in presence of NAC followed by 7.2J/cm2 photoirradiation and subsequent compound washout measured after 40 mins by CM-H2DCFDA staining-based FACSCalibur flow cytometry | Homo sapiens | 1 | ALA4376882 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!