| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4406751 | B | Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay | Homo sapiens | 25 | single protein format | Scientific Literature | ||
| 2. | ALA4406752 | A | Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay | Homo sapiens | 25 | single protein format | Scientific Literature | ||
| 3. | ALA4406753 | B | Selectivity index, ratio of IC50 for inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay to IC50 for inhibition of human ALK3 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 4. | ALA4406758 | B | Inhibition of C-terminal nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBRET assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 5. | ALA4406759 | A | Inhibition of ALK5 (unknown origin) expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter measured after 24 hrs by dual luciferase reporter assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 6. | ALA4406760 | U | Selectivity index, ratio of IC50 for inhibition of ALK5 (unknown origin) expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter measured after 24 hrs by dual luciferase reporter assay to IC50 for inhibition of C-terminal nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBRET assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 7. | ALA4406761 | A | Apparent permeability across apical to basolateral membrane in human Caco2 cells at 5 uM incubated for 120 mins in orbital shaker by LC-QTOF/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4406762 | A | Apparent permeability across basolateral to apical membrane in human Caco2 cells at 5 uM incubated for 120 mins in orbital shaker by LC-QTOF/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4406763 | A | Efflux ratio of apparent permeability across basolateral to apical membrane over apical to basolateral membrane in human Caco2 cells at 5 uM incubated for 120 mins in orbital shaker by LC-QTOF/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4406764 | A | Cmax in CB17 SCID mouse at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA4406765 | A | AUC infinity in CB17 SCID mouse at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA4406766 | A | Half life in CB17 SCID mouse at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA4406767 | A | Drug concentration in CB17 SCID mouse brain at 100 mg/kg, po measured after 4 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA4406768 | A | Ratio of total drug concentration from brain to plasma in CB17 SCID mouse at 100 mg/kg, po measured after 4 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4406769 | B | Inhibition of human ERG expressed in HEK293 cells measured after 5 mins by whole cell patch clamp method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4406770 | B | Inhibition of ALK1 (unknown origin) at 1 uM | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 17. | ALA4406771 | B | Inhibition of ALK2 (unknown origin) at 1 uM | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 18. | ALA4406772 | B | Inhibition of ALK3 (unknown origin) at 1 uM | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 19. | ALA4406773 | B | Inhibition of ALK6 (unknown origin) at 1 uM | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 20. | ALA4406774 | B | Inhibition of ARAF (unknown origin) at 1 uM | Homo sapiens | 3 | single protein format | Scientific Literature |
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