# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4352637 | ADME | Inhibition of N-terminal His6-tagged recombinant full length human p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay | Homo sapiens | 16 | ALA4350965 | cell-based format | Scientific Literature | |
2. | ALA4352638 | Binding | Inhibition of recombinant human full-length His-tagged PI3K p110gamma expressed in baculovirus expression system using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay | Homo sapiens | 23 | ALA4350965 | assay format | Scientific Literature | |
3. | ALA4352639 | Binding | Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay | Homo sapiens | 23 | ALA4350965 | cell-based format | Scientific Literature | |
4. | ALA4352640 | Binding | Selectivity ratio of IC50 for N-terminal His6-tagged recombinant full length human p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells to IC50 for recombinant human full-length His-tagged PI3K p110gamma expressed in baculovirus expression system | Homo sapiens | 6 | ALA4350965 | cell-based format | Scientific Literature | |
5. | ALA4352641 | Binding | Inhibition of recombinant human full-length His-tagged PI3K p110gamma expressed in baculovirus expression system at 1 uM using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay relative to control | Homo sapiens | 17 | ALA4350965 | assay format | Scientific Literature | |
6. | ALA4352642 | Binding | Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells at 1 uM using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay relative to control | Homo sapiens | 17 | ALA4350965 | cell-based format | Scientific Literature | |
7. | ALA4352643 | ADME | Inhibition of N-terminal His6-tagged recombinant full length human p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells at 1 uM using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay relative to control | Homo sapiens | 20 | ALA4350965 | cell-based format | Scientific Literature | |
8. | ALA4352645 | Binding | Inhibition of PI3Kgamma in rat RAW264.7 cells assessed as reduction in C5a-stimulated AKT phosphorylation at Ser473 residue preincubated for 30 mins followed by C5a-stimulation and measured after 5 mins | Rattus norvegicus | 19 | ALA4350965 | cell-based format | Scientific Literature | |
9. | ALA4352646 | Binding | Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in antihuman IgM-stimulated AKT phosphorylation at Ser473 residue preincubated for 60 mins followed by antihuman IgM stimulation and measured after 15 mins | Homo sapiens | 19 | ALA4350965 | cell-based format | Scientific Literature | |
10. | ALA4352647 | ADME | Stability in rat liver microsomes assessed as parent compound remaining at 1 uM measured after 30 mins in presence of NADPH generating system | Rattus norvegicus | 19 | ALA4350965 | microsome format | Scientific Literature | |
11. | ALA4352648 | ADME | Stability in human liver microsomes assessed as parent compound remaining at 1 uM measured after 30 mins in presence of NADPH generating system | Homo sapiens | 19 | ALA4350965 | microsome format | Scientific Literature |