# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4357677 | B | Inhibition of Serratia marcescens chitinase b catalytic domain overexpressed in Escherichia coli BL21(DE3) cells at 1 uM using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Serratia marcescens | 23 | ALA4354842 | cell-based format | Scientific Literature | |
2. | ALA4357678 | B | Inhibition of Ostrinia furnacalis chitinase h catalytic domain overexpressed in Pichia pastoris at 1 uM using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Ostrinia furnacalis | 23 | ALA4354842 | assay format | Scientific Literature | |
3. | ALA4357679 | B | Inhibition of human acidic mammalian chitinase catalytic domain overexpressed in Pichia pastoris at 10 uM using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Homo sapiens | 23 | ALA4354842 | assay format | Scientific Literature | |
4. | ALA4357680 | B | Inhibition of human CHIT1 catalytic domain overexpressed in Pichia pastoris at 10 uM using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Homo sapiens | 23 | ALA4354842 | assay format | Scientific Literature | |
5. | ALA4357681 | B | Selectivity ratio of Ki for inhibition of mouse acidic mammalian chitinase catalytic domain overexpressed in Pichia pastoris to Ki for inhibition of mouse CHIT1 catalytic domain overexpressed in Pichia pastoris | Mus musculus | 1 | ALA4354842 | assay format | Scientific Literature | |
6. | ALA4357682 | B | Selectivity ratio of Ki for inhibition of human acidic mammalian chitinase catalytic domain overexpressed in Pichia pastoris to Ki for inhibition of human CHIT1 catalytic domain overexpressed in Pichia pastoris | Homo sapiens | 1 | ALA4354842 | assay format | Scientific Literature | |
7. | ALA4357683 | B | Inhibition of Serratia marcescens chitinase b catalytic domain overexpressed in Escherichia coli BL21(DE3) cells using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Serratia marcescens | 2 | ALA4354842 | cell-based format | Scientific Literature | |
8. | ALA4357684 | B | Inhibition of Ostrinia furnacalis chitinase h catalytic domain overexpressed in Pichia pastoris using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Ostrinia furnacalis | 2 | ALA4354842 | assay format | Scientific Literature | |
9. | ALA4357685 | B | Inhibition of mouse acidic mammalian chitinase catalytic domain overexpressed in Pichia pastoris using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Mus musculus | 2 | ALA4354842 | assay format | Scientific Literature | |
10. | ALA4357686 | B | Inhibition of mouse CHIT1 catalytic domain overexpressed in Pichia pastoris using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Mus musculus | 2 | ALA4354842 | assay format | Scientific Literature | |
11. | ALA4357687 | B | Inhibition of human acidic mammalian chitinase catalytic domain overexpressed in Pichia pastoris using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Homo sapiens | 2 | ALA4354842 | assay format | Scientific Literature | |
12. | ALA4357688 | B | Inhibition of human CHIT1 catalytic domain overexpressed in Pichia pastoris using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis | Homo sapiens | 2 | ALA4354842 | assay format | Scientific Literature | |
13. | ALA4357691 | F | Invivo inhibition of human chitinase in C57BL/6 mouse assesed as reduction in bleomycin-induced chitinase level in BALF at 2 ug/mouse, ip administered for 11 days and measured on day 12 by necropsy analysis | Mus musculus | 1 | ALA4354842 | organism-based format | Scientific Literature | |
14. | ALA4357692 | B | Inhibition of chitinase in mouse BALF at 40 ug using 4-MU-(GlcNAc)2 substrate as substrate after 15 mins relative to control | Mus musculus | 1 | ALA4354842 | single protein format | Scientific Literature | |
15. | ALA4357693 | B | Inhibition of chitinase in mouse BALF at 1 ug using 4-MU-(GlcNAc)2 substrate as substrate after 15 mins relative to control | Mus musculus | 1 | ALA4354842 | single protein format | Scientific Literature | |
16. | ALA4357694 | F | Antifibrotic activity in bleomycin-induced C57BL/6 mouse model of pulmonary fibrosis assessed as effect on Chit1 expression at 2 ug/mouse, ip administered for 11 days and measured on day 12 post treatment by RT-qPCR analysis | Mus musculus | 1 | ALA4354842 | organism-based format | Scientific Literature | |
17. | ALA4357695 | F | Antifibrotic activity in bleomycin-induced C57BL/6 mouse model of pulmonary fibrosis assessed as effect on Areg expression at 2 ug/mouse, ip administered for 11 days and measured on day 12 post treatment by RT-qPCR analysis | Mus musculus | 1 | ALA4354842 | organism-based format | Scientific Literature | |
18. | ALA4357696 | F | Antifibrotic activity in bleomycin-induced C57BL/6 mouse model of pulmonary fibrosis assessed as effect on TGFbeta expression at 2 ug/mouse, ip administered for 11 days and measured on day 12 post treatment by RT-qPCR analysis | Mus musculus | 1 | ALA4354842 | organism-based format | Scientific Literature | |
19. | ALA4357697 | F | Antifibrotic activity in bleomycin-induced C57BL/6 mouse model of pulmonary fibrosis assessed as effect on IL33 expression at 2 ug/mouse, ip administered for 11 days and measured on day 12 post treatment by RT-qPCR analysis | Mus musculus | 1 | ALA4354842 | organism-based format | Scientific Literature | |
20. | ALA4357698 | F | Antifibrotic activity in bleomycin-induced C57BL/6 mouse model of pulmonary fibrosis assessed as effect on IL5 expression at 2 ug/mouse, ip administered for 11 days and measured on day 12 post treatment by RT-qPCR analysis | Mus musculus | 1 | ALA4354842 | organism-based format | Scientific Literature |