# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4307491 | B | Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye based FLIPR assay | Homo sapiens | 30 | ALA4304797 | cell-based format | Scientific Literature | |
2. | ALA4307492 | B | Inhibition of rat TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye based FLIPR assay | Rattus norvegicus | 2 | ALA4304797 | cell-based format | Scientific Literature | |
3. | ALA4307493 | A | Mean residence time in Sprague-Dawley rat at 1 mg/kg, iv measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 12 | ALA4304797 | organism-based format | Scientific Literature | |
4. | ALA4307494 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 12 | ALA4304797 | organism-based format | Scientific Literature | |
5. | ALA4307495 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 10 | ALA4304797 | organism-based format | Scientific Literature | |
6. | ALA4307496 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 10 | ALA4304797 | organism-based format | Scientific Literature | |
7. | ALA4307497 | A | Unbound fraction in Sprague-Dawley rat plasma | Rattus norvegicus | 7 | ALA4304797 | cell-free format | Scientific Literature | |
8. | ALA4307498 | A | Unbound clearance in Sprague-Dawley rat | Rattus norvegicus | 8 | ALA4304797 | assay format | Scientific Literature | |
9. | ALA4307499 | P | Lipophilicity, chromatographic hydrophobicity index of compound at pH 7.4 | 28 | ALA4304797 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4307500 | A | Unbound volume of distribution at steady state in Sprague-Dawley rat | Rattus norvegicus | 2 | ALA4304797 | assay format | Scientific Literature |