| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4426615 | B | Inhibition of recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 expressed in baculovirus infected insect cells using 4-MU-NANA as substrate preincubated for 30 mins followed by substrate addition by microplate reader analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 5 | ALA4425127 | cell-based format | Scientific Literature | |
| 2. | ALA4426616 | B | Inhibition of zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 E119V/I222L double mutant expressed in baculovirus infected insect cells using 4-MU-NANA as substrate preincubated for 30 mins followed by substrate addition by microplate reader analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 5 | ALA4425127 | cell-based format | Scientific Literature | |
| 3. | ALA4426617 | B | Inhibition of recombinant Influenza A virus (A/Anhui/1/2013(H7N9)) Neuraminidase N9 expressed in baculovirus infected insect cells using 4-MU-NANA as substrate preincubated for 30 mins followed by substrate addition by microplate reader analysis | Influenza A virus | 5 | ALA4425127 | cell-based format | Scientific Literature | |
| 4. | ALA4426618 | B | Inhibition of zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Shanghai/2/2013(H7N9)) Neuraminidase N9 R294K mutant expressed in baculovirus infected insect cells using 4-MU-NANA as substrate preincubated for 30 mins followed by substrate addition by microplate reader analysis | Influenza A virus (A/Shanghai/02/2013(H7N9)) | 5 | ALA4425127 | cell-based format | Scientific Literature | |
| 5. | ALA4426619 | P | Aqueous solubility of compound | 3 | ALA4425127 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4426620 | B | Binding affinity to recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 expressed in baculovirus infected insect cells assessed as association rate constant measured up to 400 sec by surface plasmon resonance analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 7. | ALA4426621 | B | Binding affinity to recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 expressed in baculovirus infected insect cells assessed as dissociation rate constant measured up to 400 sec by surface plasmon resonance analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 8. | ALA4426622 | B | Binding affinity to zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 E119V/I222L double mutant expressed in baculovirus infected insect cells assessed as association rate constant measured up to 400 sec by surface plasmon resonance analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 9. | ALA4426623 | B | Binding affinity to zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 E119V/I222L double mutant expressed in baculovirus infected insect cells assessed as dissociation rate constant measured up to 400 sec by surface plasmon resonance analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 10. | ALA4426624 | B | Binding affinity to recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 expressed in baculovirus infected insect cells measured up to 400 sec by surface plasmon resonance analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 11. | ALA4426625 | B | Binding affinity to zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 E119V/I222L double mutant expressed in baculovirus infected insect cells measured up to 400 sec by surface plasmon resonance analysis | Influenza A virus (A/Moscow/10/1999(H3N2)) | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 12. | ALA4426628 | A | Binding affinity to bovine serum albumin at 810 nM measured up to 160 sec | Bos taurus | 3 | ALA4425127 | single protein format | Scientific Literature | |
| 13. | ALA4426629 | B | Binding affinity to zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Shanghai/2/2013(H7N9)) Neuraminidase N9 R294K mutant tetramer expressed in baculovirus infected insect cells at 1:1 compound to N9 tetramer ratio after 3 hrs by analytical ultracentrifugation method | Influenza A virus (A/Shanghai/02/2013(H7N9)) | 1 | ALA4425127 | cell-based format | Scientific Literature | |
| 14. | ALA4426630 | F | Antiviral activity against Influenza A virus (A/Moscow/10/99(H3N2)) expressing A/Puerto Rico/8/34(H1N1) genes infected in MDCK cells assessed as reduction in viral replication after 72 hrs by hemagglutination test | Influenza A virus | 4 | ALA4425127 | organism-based format | Scientific Literature | |
| 15. | ALA4426631 | F | Antiviral activity against A/Puerto Rico/8/34(H1N1) genes expressing anamivir/oseltamivir resistant Influenza A virus (A/Moscow/10/99(H3N2)) harboring Neuraminidase N2 E119V/I222L double mutant infected in MDCK cells assessed as reduction in viral replication after 72 hrs by hemagglutination test | Influenza A virus | 4 | ALA4425127 | organism-based format | Scientific Literature | |
| 16. | ALA4426632 | F | Antiviral activity against Influenza A virus (A/Anhui/1/2013(H7N9)) expressing A/Puerto Rico/8/34(H1N1) genes infected in MDCK cells assessed as reduction in viral replication after 72 hrs by hemagglutination test | Influenza A virus | 4 | ALA4425127 | organism-based format | Scientific Literature | |
| 17. | ALA4426633 | F | Antiviral activity against A/Puerto Rico/8/34(H1N1) genes expressing anamivir/oseltamivir resistant Influenza A virus (A/Shanghai/2/2013(H7N9)) harboring Neuraminidase N9 R294K mutant infected in MDCK cells assessed as reduction in viral replication after 72 hrs by hemagglutination test | Influenza A virus (A/Shanghai/02/2013(H7N9)) | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 18. | ALA4426634 | A | Cytotoxicity against MDCK cells assessed as reduction in cell viability after 72 hrs by MTT assay | Canis lupus familiaris | 4 | ALA4425127 | cell-based format | Scientific Literature | |
| 19. | ALA4426635 | F | Induction of viral aggregation in Influenza A virus (A/Moscow/10/99(H3N2)) at 1 mM after 3 hrs by transmission electron microscopic analysis | Influenza A virus | 1 | ALA4425127 | organism-based format | Scientific Literature | |
| 20. | ALA4426636 | F | Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells assessed as plaque reduction after 72 hrs by toluidine blue staining based method | Influenza A virus | 1 | ALA4425127 | organism-based format | Scientific Literature |
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