# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4418717 | Binding | Substrate activity at LRAT in bovine RPE microsomes at 1 mM incubated for 1 hr at 37 degC by HPLC analysis relative to corresponding primary alcohols | Bos taurus | 36 | ALA4418488 | assay format | Patent Bioactivity Data | |
2. | ALA4418718 | Functional | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as effect on thickness of outer nuclear layer at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by SDOCT and ERG analysis | Mus musculus | 12 | ALA4418488 | organism-based format | Patent Bioactivity Data | |
3. | ALA4418719 | Binding | Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production pre-incubated at room temperature for 5 mins before all-trans-retinol addition and further incubated for 15 mins to 2 hrs in presence of CRALBP by normal phase HPLC analysis | Bos taurus | 36 | ALA4418488 | assay format | Patent Bioactivity Data | |
4. | ALA4418720 | Toxicity | Toxicity in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse model of intense light-induced retinal degeneration at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by SDOCT and ERG analysis | Mus musculus | 12 | ALA4418488 | organism-based format | Patent Bioactivity Data |