| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4410947 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM measured at 15 mins in presence of phase 1 metabolism cofactors by LC-MS/MS analysis | Homo sapiens | 17 | microsome format | Scientific Literature | ||
| 2. | ALA4410948 | A | Hepatic intrinsic clearance in human Hepatocytes assessed per at 1 uM measured upto 90 mins by LC-MS/MS analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 3. | ALA4410949 | B | Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 peptide as substrate incubated for 1 hr by LanthaScreen assay | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 4. | ALA4410950 | B | Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 5. | ALA4410951 | B | Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 6. | ALA4410952 | B | Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assay | Homo sapiens | 19 | single protein format | Scientific Literature | ||
| 7. | ALA4410953 | P | Kinetic aqueous solubility of compound in phosphate buffer at pH 7.4 at 100 uM at 20 degree C shaken for 24 hrs by HPLC analysis | 19 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4410954 | P | Lipophilicity, chromatographic hydrophobicity index of compound at 0.5 mM at pH 6.5 by UPLC-UV analysis | 19 | small-molecule physicochemical format | Scientific Literature |
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