# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4401029 | A | Substrate activity at recombinant human NEP (Tyr52 to Trp750 residues) expressed in HEK293 cells assessed as enzyme-mediated degradation onset time at 1 mM by MALDI-TOF MS analysis | Homo sapiens | 7 | ALA4400521 | cell-based format | Scientific Literature | |
2. | ALA4401030 | A | Substrate activity at recombinant human C-terminal His6-tagged KLKB1 (Pro19 to Ser262 residues) expressed in mammalian expression system assessed as enzyme-mediated degradation onset time at 1 mM by MALDI-TOF MS analysis | Homo sapiens | 6 | ALA4400521 | assay format | Scientific Literature | |
3. | ALA4401044 | A | Substrate activity at recombinant human C-terminal His6-tagged KLKB1 (Pro19 to Ser262 residues) expressed in mammalian expression system assessed as compound half life by LC-MS analysis | Homo sapiens | 7 | ALA4400521 | assay format | Scientific Literature | |
4. | ALA4401045 | A | Substrate activity at recombinant human NEP (Tyr52 to Trp750 residues) expressed in HEK293 cells assessed as compound half life by LC-MS analysis | Homo sapiens | 7 | ALA4400521 | cell-based format | Scientific Literature | |
5. | ALA4401046 | A | Substrate activity at KLKB1 in human plasma assessed as compound half life by LC-MS analysis | Homo sapiens | 7 | ALA4400521 | cell-free format | Scientific Literature | |
6. | ALA4401047 | B | Displacement of [125I]-(Glp1,Nle11,Try14)apelin-13 from recombinant rat EGFP-fused apelin receptor expressed in CHO cell membrane measured after 3 hrs | Rattus norvegicus | 9 | ALA4400521 | cell-based format | Scientific Literature | |
7. | ALA4401048 | F | Activation of recombinant human APJ expressed in rat Chem5 cells co-expressing Galpha15 by Calcium 6-QF dye based fluorescence assay | Homo sapiens | 9 | ALA4400521 | cell-based format | Scientific Literature | |
8. | ALA4401049 | F | Blood pressure lowering activity in anesthetized mouse assessed as change in mean arterial blood pressure at 1.4 uM/kg, iv | Mus musculus | 9 | ALA4400521 | organism-based format | Scientific Literature |